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Literature summary extracted from
- Effects of ambroxol on alginate of mature Pseudomonas aeruginosa biofilms (2008), Curr. Microbiol., 57, 1-7.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.1.1.132 | ambroxol | i.e. 2-amino-3,5-dibromo-N-[trans-4-hydroxycyclohexyl]benzylamine, inhibits GMD activity, reduces the production of alginate, the expression of the important genes, and affects the structure of mucoid Pseudomonas aeruginosa biofilms, overview; reduces activity of the key enzyme GMD in alginate biosynthesis in a concentration-dependent manner | Pseudomonas aeruginosa |  |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.1.1.132 | additional information | Pseudomonas aeruginosa | GMD is the key enzyme in alginate biosynthesis. Biofilm-forming bacteria Pseudomonas aeruginosa is a common pathogen in mechanically ventilated newborns, which can cause life-threatening infections | ? | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.1.1.132 | Pseudomonas aeruginosa | - |
- |
- |
| 1.1.1.132 | Pseudomonas aeruginosa | P11759 | - |
- |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.1.1.132 | additional information | GMD is the key enzyme in alginate biosynthesis. Biofilm-forming bacteria Pseudomonas aeruginosa is a common pathogen in mechanically ventilated newborns, which can cause life-threatening infections | Pseudomonas aeruginosa | ? | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 1.1.1.132 | GDP-mannose dehydrogenase | - |
Pseudomonas aeruginosa |
| 1.1.1.132 | GMD | - |
Pseudomonas aeruginosa |
| 1.1.1.132 | guanosine diphospho-D-mannose dehydrogenase | - |
Pseudomonas aeruginosa |
Temperature Optimum [°C]
| EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 1.1.1.132 | 37 | - |
assay at | Pseudomonas aeruginosa |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 1.1.1.132 | 7 | - |
assay at | Pseudomonas aeruginosa |
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Release 2023.1 (January 2023)
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