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Literature summary extracted from
- Silencing the genes for dopa decarboxylase or dopachrome conversion enzyme reduces melanization of foreign targets in Anopheles gambiae (2008), Comp. Biochem. Physiol. B, 150, 403-408.
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 4.1.1.28 | knockdown (silencing) of gene expression (RNA interference) results in a significant reduction of melanization of Sephadex beads at 24 h after injection. The average proportion of mosquitoes that completely melanized beads is 28% compared with 64% when the control green fluorescent protein is injected | Anopheles gambiae |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 4.1.1.28 | L-Dopa | Anopheles gambiae | - |
dopamine + CO2 | dopamine can serve as the catecholamine substrate for melanin production | ? |  |
| 4.1.1.28 | additional information | Anopheles gambiae | enzyme is involved in the production of melanin, a complex biochemical process in which several enzymes may play a role | ? | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 4.1.1.28 | Anopheles gambiae | O61717 | isoform 1, descended from accession number AF063021; strain G3, the strain has the ability to melanize malaria parasites | - |
| 4.1.1.28 | Anopheles gambiae | O61718 | isoform 2, descended from accession number AF063021; strain G3, the strain has the ability to melanize malaria parasites | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 4.1.1.28 | L-Dopa | - |
Anopheles gambiae | dopamine + CO2 | dopamine can serve as the catecholamine substrate for melanin production | ? | |
| 4.1.1.28 | additional information | enzyme is involved in the production of melanin, a complex biochemical process in which several enzymes may play a role | Anopheles gambiae | ? | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 4.1.1.28 | DDC | - |
Anopheles gambiae |
| 4.1.1.28 | DOPA decarboxylase | - |
Anopheles gambiae |
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