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Literature summary extracted from
- The role of phosphodiesterases in schizophrenia: therapeutic implications (2008), CNS Drugs, 22, 983-993.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.1.4.17 | dipyridamole | inhibits with micromolar potency | Homo sapiens |  |
| 3.1.4.17 | dipyridamole | inhibits with micromolar potency | Rattus norvegicus | |
| 3.1.4.17 | isobutylmethylxanthine | inhibits with micromolar potency | Homo sapiens | |
| 3.1.4.17 | isobutylmethylxanthine | inhibits with micromolar potency | Rattus norvegicus | |
| 3.1.4.17 | MP-10 | - |
Homo sapiens | |
| 3.1.4.17 | papaverine | competitive inhibitor | Homo sapiens | |
| 3.1.4.17 | papaverine | competitive inhibitor | Rattus norvegicus | |
| 3.1.4.17 | PQ-10 | - |
Homo sapiens | |
| 3.1.4.17 | TP-10 | - |
Homo sapiens | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.1.4.17 | Homo sapiens | - |
- |
- |
| 3.1.4.17 | Rattus norvegicus | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.1.4.17 | brain | PDE10A is strongly expressed in the brain, highly expressed in striatal complex including caudate putamen, nucleus accumbens, and olfacory tubercle | Homo sapiens | - |
| 3.1.4.17 | brain | PDE10A is strongly expressed in the brain, highly expressed in striatal complex including caudate putamen, nucleus accumbens, and olfacory tubercle | Rattus norvegicus | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.1.4.17 | 3',5'-cAMP + H2O | - |
Homo sapiens | 5'-AMP | - |
? | |
| 3.1.4.17 | 3',5'-cAMP + H2O | - |
Rattus norvegicus | 5'-AMP | - |
? | |
| 3.1.4.17 | 3',5'-cGMP + H2O | - |
Homo sapiens | 5'-GMP | - |
? | |
| 3.1.4.17 | 3',5'-cGMP + H2O | - |
Rattus norvegicus | 5'-GMP | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 3.1.4.17 | PDE10A | hydrolyses both 3',5'-cAMP and 3',5'-cGMP although with different kinetic parameters | Homo sapiens |
| 3.1.4.17 | PDE10A | hydrolyses both 3',5'-cAMP and 3',5'-cGMP although with different kinetic parameters | Rattus norvegicus |
IC50 Value
| EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|---|
| 3.1.4.17 | 0.000036 | - |
- |
Rattus norvegicus | papaverine | |
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Release 2023.1 (January 2023)
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