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Literature summary extracted from

  • Tayama, Y.; Miyake, K.; Sugihara, K.; Kitamura, S.; Kobayashi, M.; Morita, S.; Ohta, S.; Kihira, K.
    Developmental changes of aldehyde oxidase activity in young Japanese children (2007), Clin. Pharmacol. Ther., 81, 567-572.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.2.3.1 additional information significant correlations between aldehyde oxidase activity and various growth indices like age, body weight, body surface area, and liver volume. Aldehyde oxidase activity rapidly increases with increase of age up to about 1 year. No differences in sex, but individual variation of developmental changes in aldehyde oxidase activity among monozygotic twins Homo sapiens

Application

EC Number Application Comment Organism
1.2.3.1 medicine aldehyde oxidase plays an important role in metabolizing many drugs, so aldehyde oxidase activity in individual patients may be a useful parameter for dose adjustment to avoid severe toxicity. Aldehyde oxidase activity is immature in children below 1 year of age, dose adjustment based on individual aldehyde oxidase activity shall be made for such patients Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
1.2.3.1 Homo sapiens
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 Japanese children
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.2.3.1 urine
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.2.3.1 N1-methylnicotinamide + H2O + O2
-
 Homo sapiens N1-methyl-2-pyridone-5-carboxamide + N1-methyl-4-pyridone-3-carboxamide + H2O2
-
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