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Literature summary extracted from

  • Garces, C.; Lopez-Simon, L.; Rubio, R.; Benavente, M.; Cano, B.; Ortega, H.; de Oya, M.
    High-density lipoprotein cholesterol and paraoxonase 1 (PON1) genetics and serum PON1 activity in prepubertal children in Spain (2008), Clin. Chem. Lab. Med., 46, 809-813.
    View publication on PubMed

Protein Variants

EC Number Protein Variants Comment Organism
3.1.1.2 L55M the polymorphism accounts for 73% of PON1 activity Homo sapiens
3.1.1.2 Q192R the polymorphism accounts for 69% of PON1 activity, the 192RR genotype carriers have the highest PON1 activity, whereas the the 192QQ genotype carriers have the lowest activity, with the heterozygote 192Q/R having intermediate activity Homo sapiens
3.1.8.1 L55M the polymorphism accounts for 73% of PON1 activity Homo sapiens
3.1.8.1 Q192R the polymorphism accounts for 69% of PON1 activity, the 192RR genotype carriers have the highest PON1 activity, whereas the the 192QQ genotype carriers have the lowest activity, with the heterozygote 192Q/R having intermediate activity Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.1.1.2 Homo sapiens P27169
-
-
3.1.8.1 Homo sapiens P27169
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.1.2 serum
-
 Homo sapiens
-
3.1.8.1 serum
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.1.2 4-(chloromethyl)phenyl acetate + H2O
-
 Homo sapiens 4-chloromethyl phenol + acetate
-
 ?
3.1.1.2 phenyl acetate + H2O
-
 Homo sapiens phenol + acetate
-
 ?
3.1.8.1 chlorpyrifos-oxon + H2O
-
 Homo sapiens 3,5,6-trichloro-2-pyridinol + diethyl phosphate
-
 ?
3.1.8.1 diazoxon + H2O
-
 Homo sapiens 2-isopropyl-6-methyl-pyrimidin-4-ol + diethyl phosphate
-
 ?
3.1.8.1 paraoxon + H2O
-
 Homo sapiens diethylphosphate + 4-nitrophenol
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.8.1 paraoxonase 1
-
 Homo sapiens
3.1.8.1 PON1
-
 Homo sapiens