EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
4.2.1.115 | CMP-pseudaminic acid | mapping of the dynamic interactions of the enzyme with the inhibitor, overview | Helicobacter pylori |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
4.2.1.115 | additional information | Helicobacter pylori | dependence of O-linked flagellin glycosylation on PseB, cross-talk between the Pse and alpha-D-QuiNAc4NAc, i.e. 2,4-diacetamido-2,4,6-trideoxy-a-d-Glc, pathways via PseB | ? | - |
? | |
4.2.1.115 | UDP-N-acetylglucosamine | Helicobacter pylori | the enzyme is required for pseudaminic acid biosynthesis, which is required for O-linked flagellin glycosylation | UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hex-4-ulose + H2O | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
4.2.1.115 | Helicobacter pylori | - |
- |
- |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
4.2.1.115 | additional information | dependence of O-linked flagellin glycosylation on PseB, cross-talk between the Pse and alpha-D-QuiNAc4NAc, i.e. 2,4-diacetamido-2,4,6-trideoxy-a-d-Glc, pathways via PseB | Helicobacter pylori | ? | - |
? | |
4.2.1.115 | additional information | PseB catalyzes an additional C5 epimerization forming UDP-2-acetamido-2,6-dideoxy-alpha-D-xylo-hexos-4-ulose | Helicobacter pylori | ? | - |
? | |
4.2.1.115 | UDP-N-acetylglucosamine | the enzyme is required for pseudaminic acid biosynthesis, which is required for O-linked flagellin glycosylation | Helicobacter pylori | UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hex-4-ulose + H2O | - |
? | |
4.2.1.115 | UDP-N-acetylglucosamine | NMR reaction analysis, substrate binding at the active site, mapping of dynamic interactions of the enzyme with its ligand, molecular docking, overview | Helicobacter pylori | UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hex-4-ulose + H2O | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
4.2.1.115 | 4,6-dehydratase/5-epimerase | - |
Helicobacter pylori |
4.2.1.115 | PseB | - |
Helicobacter pylori |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
4.2.1.115 | 7.3 | - |
assay at | Helicobacter pylori |