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Literature summary extracted from

  • Muccioli, G.G.; Labar, G.; Lambert, D.M.
    CAY10499, a novel monoglyceride lipase inhibitor evidenced by an expeditious MGL assay (2008), ChemBioChem, 9, 2704-2710.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.1.23 arachidonoyltrifluoromethylketone
-
 Homo sapiens
3.1.1.23 benzylphenylcarbamate
-
 Homo sapiens
3.1.1.23 CAY10499
-
 Homo sapiens
3.1.1.23 Disulfiram
-
 Homo sapiens
3.1.1.23 methyl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14- tetraenylphosphonofluoridate completely inhibits 4-nitophenyl acetate hydrolysis by pure human MGL at 0.1 mM Homo sapiens
3.1.1.23 additional information not inhibited by CAY10433, WWL70, and URB602 Homo sapiens
3.1.1.23 N-arachidonylmaleimide
-
 Homo sapiens
3.1.1.23 N-benzoylthiocarbamic cyclohexylethyl ester
-
 Homo sapiens
3.1.1.23 N-ethylmaleimide
-
 Homo sapiens
3.1.1.23 phenylmethylsulfonyl fluoride inhibits MGL only at very high concentrations Homo sapiens
3.1.1.23 tetrahydrolipstatin
-
 Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.1.1.23 0.2
-
 4-nitrophenyl acetate
-
 Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.1.1.23 Homo sapiens
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.1.23 2-arachidonoylglycerol + H2O
-
 Homo sapiens arachidonic acid + glycerol
-
 ?
3.1.1.23 2-oleoylglycerol + H2O
-
 Homo sapiens oleic acid + glycerol
-
 ?
3.1.1.23 4-nitrophenyl acetate + H2O
-
 Homo sapiens 4-nitrophenol + acetate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.1.23 MGL
-
 Homo sapiens
3.1.1.23 monoglycerid lipase
-
 Homo sapiens

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
3.1.1.23 0.000076
-
-
 Homo sapiens methyl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraen-1-ylphosphonofluoridate
3.1.1.23 0.0004
-
 using 2-oleoylglycerol as a substrate Homo sapiens CAY10499
3.1.1.23 0.00046
-
-
 Homo sapiens tetrahydrolipstatin
3.1.1.23 0.0005
-
 using 4-nitophenyl acetate as a substrate Homo sapiens CAY10499
3.1.1.23 0.0008
-
-
 Homo sapiens Disulfiram
3.1.1.23 0.00184
-
-
 Homo sapiens arachidonoyltrifluoromethylketone
3.1.1.23 0.0049
-
 using 2-oleoylglycerol as a substrate Homo sapiens N-arachidonylmaleimide
3.1.1.23 0.005
-
 using 4-nitophenyl acetate as a substrate Homo sapiens N-benzoylthiocarbamic cyclohexylethyl ester
3.1.1.23 0.0105
-
 using 4-nitophenyl acetate as a substrate Homo sapiens N-arachidonylmaleimide
3.1.1.23 0.02
-
 using 2-oleoylglycerol as a substrate Homo sapiens N-benzoylthiocarbamic cyclohexylethyl ester
3.1.1.23 0.028
-
-
 Homo sapiens N-ethylmaleimide