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Literature summary extracted from

  • Khaled, A.; Piotrowska, O.; Dominiak, K.; Auge, C.
    Exploring specificity of glycosyltransferases: synthesis of new sugar nucleotide related molecules as putative donor substrates (2008), Carbohydr. Res., 343, 167-178.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.4.1.56 expressed in Escherichia coli Neisseria meningitidis

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.4.1.56 2-acetamido-2-deoxy-alpha-D-glucopyranosyl 1-diphosphate
-
 Neisseria meningitidis
2.4.1.65 9-(5'-O-[(alpha,beta-L-fucopyranosyl)oxycarbonylaminosulfonyl]-beta-D-ribofuranosyl)-guanine poor competitive inhibition Homo sapiens

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.4.1.56 Mn2+
-
 Neisseria meningitidis
2.4.1.65 Mn2+ absolutely required Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.56 Neisseria meningitidis
-
-
-
2.4.1.65 Homo sapiens
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.1.56 additional information synthesized donor substrates methyl-(2-acetamido-2-deoxy-alpha-D-glucopyranosyl)-diphosphate, benzyl-(2-acetamido-2-deoxy-alpha-D-glucopyranosyl)-diphosphate, 4-phenylbutyl-(2-acetamido-2-deoxy-alpha-D-glucopyranosyl)-diphosphate and 2-acetamido-2-deoxy-alpha-D-glucopyranose 1-diphosphate show no reactivity Neisseria meningitidis ?
-
 ?
2.4.1.56 UDP-N-acetyl-D-glucosamine + beta-D-Galp-(1-4)-beta-D-Glcp-O-(CH2)6-NH-dansyl
-
 Neisseria meningitidis ?
-
 ?
2.4.1.65 GDP-beta-L-fucose + beta-D-Galp-(1,3)-beta-D-GlcNAcp-O-(CH2)6-NH-dansyl
-
 Homo sapiens GDP + beta-D-Galp-(1,3)[alpha-L-Fuc-(1,4)]-beta-D-GlcNAcp-O-(CH2)6-NH-dansyl
-
 ?
2.4.1.65 additional information FucT-III catalyzes the transfer of fucose onto position-4 or position-3 of the N-acetylglucosamine unit of disaccharides beta-D-Galp-(1,3)-beta-D-GlcpNAc or beta-D-Galp-(1,4)-beta-D-GlcpNAc, respectively. FucT-III is an inverting enzyme Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.4.1.56 LgtA
-
 Neisseria meningitidis
2.4.1.56 N-acetylglucosaminyltransferase
-
 Neisseria meningitidis
2.4.1.65 alpha-(1-3/4)-fucosyltransferase
-
 Homo sapiens
2.4.1.65 FucT-III
-
 Homo sapiens
2.4.1.65 GDP-Fuc: beta-D-Galp-(1-3/4)-beta-D-GlcpNAc-(1-4'/3')-alpha-fucosyltransferase
-
 Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.4.1.56 37
-
 assay at Neisseria meningitidis
2.4.1.65 37
-
 assay at Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.4.1.56 7.2
-
 assay at Neisseria meningitidis
2.4.1.65 6
-
 assay at Homo sapiens

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
2.4.1.56 7
-
-
 Neisseria meningitidis 2-acetamido-2-deoxy-alpha-D-glucopyranosyl 1-diphosphate
2.4.1.65 20
-
-
 Homo sapiens 9-(5'-O-[(alpha,beta-L-fucopyranosyl)oxycarbonylaminosulfonyl]-beta-D-ribofuranosyl)-guanine