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Literature summary extracted from

  • Sato, R.; Suzuki, T.; Katayose, Y.; Miura, K.; Shiiba, K.; Tateno, H.; Miki, Y.; Akahira, J.; Kamogawa, Y.; Nagasaki, S.; Yamamoto, K.; Ii, T.; Egawa, S.; Evans, D.B.; Unno, M.; Sasano, H.
    Steroid sulfatase and estrogen sulfotransferase in colon carcinoma: regulators of intratumoral estrogen concentrations and potent prognostic factors (2009), Cancer Res., 69, 914-922.
    View publication on PubMed

Application

EC Number Application Comment Organism
2.8.2.4 medicine the steroid sulfatase/estrogen sulfotransferase status of carcinoma tissue determines intratumoral estrogen levels and can be a significant prognostic factor in colon carcinoma Homo sapiens
3.1.6.2 medicine patients with no STS but estrogen sulfotransferase activity (-/+) have better clinical prognosis than all other activity pairs of these enzymes (+/-, +/+, -/-) Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.6.2 cytoplasm
-
 Homo sapiens 5737
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.6.2 estrone sulfate + H2O Homo sapiens
-
 estrone + sulfate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.8.2.4 Homo sapiens
-
-
-
3.1.6.2 Homo sapiens
-
 colon carcinoma cells
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.8.2.4 colonic adenocarcinoma cell
-
 Homo sapiens
-
3.1.6.2 colonic cancer cell immunohistochemistry: STS activity in 60% and 61% of patients with colon carcinoma, patients with no STS but estrogen sulfotransferase activity (-/+) have better clinical prognosis than all other activity pairs of these enzymes (+/-, +/+, -/-) Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.6.2 estrone sulfate + H2O
-
 Homo sapiens estrone + sulfate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.8.2.4 EST
-
 Homo sapiens
3.1.6.2 steroid sulfatase
-
 Homo sapiens
3.1.6.2 STS
-
 Homo sapiens