BRENDA - Enzyme Database show

Steroid sulfatase and estrogen sulfotransferase in colon carcinoma: regulators of intratumoral estrogen concentrations and potent prognostic factors

Sato, R.; Suzuki, T.; Katayose, Y.; Miura, K.; Shiiba, K.; Tateno, H.; Miki, Y.; Akahira, J.; Kamogawa, Y.; Nagasaki, S.; Yamamoto, K.; Ii, T.; Egawa, S.; Evans, D.B.; Unno, M.; Sasano, H.; Cancer Res. 69, 914-922 (2009)

Data extracted from this reference:

Application
EC Number
Application
Commentary
Organism
2.8.2.4
medicine
the steroid sulfatase/estrogen sulfotransferase status of carcinoma tissue determines intratumoral estrogen levels and can be a significant prognostic factor in colon carcinoma
Homo sapiens
3.1.6.2
medicine
patients with no STS but estrogen sulfotransferase activity (-/+) have better clinical prognosis than all other activity pairs of these enzymes (+/-, +/+, -/-)
Homo sapiens
Localization
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
3.1.6.2
cytoplasm
-
Homo sapiens
5737
-
Natural Substrates/ Products (Substrates)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
3.1.6.2
estrone sulfate + H2O
Homo sapiens
-
estrone + sulfate
-
-
?
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
2.8.2.4
Homo sapiens
-
-
-
3.1.6.2
Homo sapiens
-
colon carcinoma cells
-
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
2.8.2.4
colonic adenocarcinoma cell
-
Homo sapiens
-
3.1.6.2
colonic cancer cell
immunohistochemistry: STS activity in 60% and 61% of patients with colon carcinoma, patients with no STS but estrogen sulfotransferase activity (-/+) have better clinical prognosis than all other activity pairs of these enzymes (+/-, +/+, -/-)
Homo sapiens
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
3.1.6.2
estrone sulfate + H2O
-
691630
Homo sapiens
estrone + sulfate
-
-
-
?
Application (protein specific)
EC Number
Application
Commentary
Organism
2.8.2.4
medicine
the steroid sulfatase/estrogen sulfotransferase status of carcinoma tissue determines intratumoral estrogen levels and can be a significant prognostic factor in colon carcinoma
Homo sapiens
3.1.6.2
medicine
patients with no STS but estrogen sulfotransferase activity (-/+) have better clinical prognosis than all other activity pairs of these enzymes (+/-, +/+, -/-)
Homo sapiens
Localization (protein specific)
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
3.1.6.2
cytoplasm
-
Homo sapiens
5737
-
Natural Substrates/ Products (Substrates) (protein specific)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
3.1.6.2
estrone sulfate + H2O
Homo sapiens
-
estrone + sulfate
-
-
?
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
2.8.2.4
colonic adenocarcinoma cell
-
Homo sapiens
-
3.1.6.2
colonic cancer cell
immunohistochemistry: STS activity in 60% and 61% of patients with colon carcinoma, patients with no STS but estrogen sulfotransferase activity (-/+) have better clinical prognosis than all other activity pairs of these enzymes (+/-, +/+, -/-)
Homo sapiens
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
3.1.6.2
estrone sulfate + H2O
-
691630
Homo sapiens
estrone + sulfate
-
-
-
?