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Literature summary extracted from

  • Xu, Z.; Kohli, E.; Devlin, K.I.; Bold, M.; Nix, J.C.; Misra, S.
    Interactions between the quality control ubiquitin ligase CHIP and ubiquitin conjugating enzymes (2008), BMC Struct. Biol., 8, 26.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.3.2.23
-
 Danio rerio
2.3.2.27
-
 Danio rerio

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
2.3.2.23 2.9 A crystal structure of the ubiquitin ligase CHIP U-box domain complexed with UbcH5a. CHIP binds to UbcH5 and Ubc13 through similar specificity determinants located on the long loops and central helix of the CHIP U-box, and on the N-terminal helix and loops L4 and L7 of its cognate E2 enzymes including a key S-P-A motif. The determinants make different relative contributions to the overall interactions between CHIP and the two E2 enzymes. CHIP undergoes auto-ubiquitination by UbcH5 Danio rerio
2.3.2.27 2.9 A crystal structure of the ubiquitin ligase CHIP U-box domain complexed with UbcH5a. CHIP binds to UbcH5 and Ubc13 through similar specificity determinants located on the long loops and central helix of the CHIP U-box, and on the N-terminal helix and loops L4 and L7 of its cognate E2 enzymes including a key S-P-A motif. The determinants make different relative contributions to the overall interactions between CHIP and the two E2 enzymes. CHIP undergoes auto-ubiquitination by UbcH5 but not by Ubc13-Uev1a. Instead, CHIP drives the formation of unanchored polyubiquitin by Ubc13-Uev1a. CHIP also interacts productively with the class III E2 enzyme Ube2e2 Danio rerio

Organism

EC Number Organism UniProt Comment Textmining
2.3.2.23 Danio rerio Q6PC58
-
-
2.3.2.27 Danio rerio Q7ZTZ6 isoform CHIP
-

Synonyms

EC Number Synonyms Comment Organism
2.3.2.23 UbcH5A
-
 Danio rerio
2.3.2.23 ube2d1b
-
 Danio rerio
2.3.2.27 CHIP
-
 Danio rerio
2.3.2.27 STIP1 homology and U-Box containing protein 1
-
 Danio rerio