Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Kravtsov, D.V.; Matafonov, A.; Tucker, E.I.; Sun, M.F.; Walsh, P.N.; Gruber, A.; Gailani, D.
    Factor XI contributes to thrombin generation in the absence of factor XII (2009), Blood, 114, 452-458.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.4.21.27 thrombin activates fXI Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.4.21.27 recombinant human fXI is expressed in HEK-293 cells Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.21.38 corn trypsin inhibitor selectively binds and inhibits fXII and fXIIa in blood plasma Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.27 Homo sapiens P03951
-
-
3.4.21.38 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.4.21.27 affinity chromatography Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.21.27 blood platelet
-
 Homo sapiens
-
3.4.21.38 blood plasma
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.27 L-pyroglutamyl-L-prolyl-L-argininyl-p-nitroanilide + H2O
-
 Homo sapiens L-pyroglutamyl-L-prolyl-L-arginine + p-nitroaniline
-
 ?
3.4.21.27 Z-Gly-Gly-Arg-7-amido-4-methylcoumarin + H2O
-
 Homo sapiens Z-Gly-Gly-Arg + 7-amino-4-methylcoumarin
-
 ?
3.4.21.38 factor XI + H2O
-
 Homo sapiens factor XIa + ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.21.27 factor XI
-
 Homo sapiens
3.4.21.27 FXI
-
 Homo sapiens
3.4.21.38 factor XII
-
 Homo sapiens
3.4.21.38 FXII
-
 Homo sapiens
3.4.21.38 FXIIa activated factor XII Homo sapiens