BRENDA - Enzyme Database

Dinucleotide polyphosphates contribute to purinergic signalling via inhibition of adenylate kinase activity

Yegutkin, G.G.; Jankowski, J.; Jalkanen, S.; Guenthner, T.; Zidek, W.; Jankowski, V.; Biosci. Rep. 28, 189-194 (2008)

Data extracted from this reference:

Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
2.7.4.3
P1,P4-bis(adenosine-5')tetraphosphate
inhibitory to both serum adenylate kinase and endothelial adenylate kinase
Homo sapiens
2.7.4.3
P1,P4-di(uridine-5')tetraphosphate
inhibitory to both serum adenylate kinase and endothelial adenylate kinase
Homo sapiens
2.7.4.3
P1,P5-di(adenosine-5')pentaphosphate
inhibitory to both serum adenylate kinase and endothelial adenylate kinase
Homo sapiens
2.7.4.3
suramin
inhibitory to both serum adenylate kinase and endothelial adenylate kinase
Homo sapiens
2.7.4.3
uridine adenosine tetraphosphate
inhibitory to both serum adenylate kinase and endothelial adenylate kinase
Homo sapiens
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
2.7.4.3
Homo sapiens
-
-
-
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
2.7.4.3
HUVEC cell
-
Homo sapiens
-
2.7.4.3
serum
-
Homo sapiens
-
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
2.7.4.3
P1,P4-bis(adenosine-5')tetraphosphate
inhibitory to both serum adenylate kinase and endothelial adenylate kinase
Homo sapiens
2.7.4.3
P1,P4-di(uridine-5')tetraphosphate
inhibitory to both serum adenylate kinase and endothelial adenylate kinase
Homo sapiens
2.7.4.3
P1,P5-di(adenosine-5')pentaphosphate
inhibitory to both serum adenylate kinase and endothelial adenylate kinase
Homo sapiens
2.7.4.3
suramin
inhibitory to both serum adenylate kinase and endothelial adenylate kinase
Homo sapiens
2.7.4.3
uridine adenosine tetraphosphate
inhibitory to both serum adenylate kinase and endothelial adenylate kinase
Homo sapiens
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
2.7.4.3
HUVEC cell
-
Homo sapiens
-
2.7.4.3
serum
-
Homo sapiens
-