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Literature summary extracted from

  • Vovk, A.I.; Mischenko, I.M.; Tanchuk, V.Y.; Kachkovskii, G.A.; Sheiko, S.Y.; Kolodyazhnyi, O.I.; Kukhar, V.P.
    Stereoselectivity of binding of alpha-(N-benzylamino)benzylphosphonic acids to prostatic acid phosphatase (2008), Bioorg. Med. Chem. Lett., 18, 4620-4623.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.3.2 (1R)-1-phenyl-N-[(S)-phenyl(phosphono)methyl]ethanaminium chloride
-
 Homo sapiens
3.1.3.2 (1R)-N-[(S)-(4-methoxyphenyl)(phosphono)methyl]-1-phenylethanaminium chloride
-
 Homo sapiens
3.1.3.2 (1S)-1-phenyl-N-[(R)-phenyl(phosphono)methyl]ethanaminium chloride
-
 Homo sapiens
3.1.3.2 (1S)-N-[(R)-(4-methoxyphenyl)(phosphono)methyl]-1-phenylethanaminium chloride
-
 Homo sapiens
3.1.3.2 (R)-N-benzyl(phenyl)phosphonomethanaminium chloride
-
 Homo sapiens
3.1.3.2 (S)-N-benzyl(phenyl)phosphonomethanaminium chloride
-
 Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.1.3.2 0.14
-
 1-naphthyl phosphate
-
 Homo sapiens
3.1.3.2 1.95
-
 O-phospho-L-tyrosine
-
 Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.1.3.2 Homo sapiens P15309
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.3.2 prostate
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.3.2 1-naphthyl phosphate + H2O
-
 Homo sapiens 1-naphthol + phosphate
-
 ?
3.1.3.2 O-phospho-L-tyrosine + H2O
-
 Homo sapiens phosphate + L-tyrosine
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.3.2 acid phosphatase
-
 Homo sapiens

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
3.1.3.2 0.000005
-
 determined by O-phosphotyrosine enzyme assay Homo sapiens (R)-N-benzyl(phenyl)phosphonomethanaminium chloride
3.1.3.2 0.000018
-
 determined by O-phosphotyrosine enzyme assay Homo sapiens (1S)-N-[(R)-(4-methoxyphenyl)(phosphono)methyl]-1-phenylethanaminium chloride
3.1.3.2 0.000026
-
 determined by O-phosphotyrosine enzyme assay Homo sapiens (1S)-1-phenyl-N-[(R)-phenyl(phosphono)methyl]ethanaminium chloride
3.1.3.2 0.000198
-
 determined by O-phosphotyrosine enzyme assay Homo sapiens (S)-N-benzyl(phenyl)phosphonomethanaminium chloride
3.1.3.2 0.00107
-
 determined by O-phosphotyrosine enzyme assay Homo sapiens (1R)-N-[(S)-(4-methoxyphenyl)(phosphono)methyl]-1-phenylethanaminium chloride
3.1.3.2 0.00121
-
 determined by O-phosphotyrosine enzyme assay Homo sapiens (1R)-1-phenyl-N-[(S)-phenyl(phosphono)methyl]ethanaminium chloride