Literature summary extracted from

Mabiala-Bassiloua, C.G.; Zwolinska, M.; Therisod, H.; Sygusch, J.; Therisod, M.
Separate synthesis and evaluation of D-glucitol 1,6-bisphosphate and mannitol bis-phosphate, as competitive inhibitors of fructose bis-phosphate aldolases (2008), Bioorg. Med. Chem. Lett., 18, 1735-1737.

Application

EC Number	Application	Comment	Organism
4.1.2.13	medicine	inhibitors of class II Fba can be potential drugs against microorganisms	Saccharomyces cerevisiae
4.1.2.13	medicine	inhibitors of class II Fba can be potential drugs against microorganisms	Helicobacter pylori

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
4.1.2.13	D-glucitol 1,6-bisphosphate	competitive inhibitor	Helicobacter pylori
4.1.2.13	D-glucitol 1,6-bisphosphate	competitive inhibitor	Oryctolagus cuniculus
4.1.2.13	D-glucitol 1,6-bisphosphate	competitive inhibitor, better inhibitor	Saccharomyces cerevisiae
4.1.2.13	D-mannitol 1,6-bisphosphate	competitive inhibitor, better inhibitor	Helicobacter pylori
4.1.2.13	D-mannitol 1,6-bisphosphate	competitive inhibitor	Oryctolagus cuniculus
4.1.2.13	D-mannitol 1,6-bisphosphate	competitive inhibitor	Saccharomyces cerevisiae

KM Value [mM]

EC Number	KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
4.1.2.13	0.02	-	D-fructose 1,6-bisphosphate	-	Oryctolagus cuniculus
4.1.2.13	0.2	-	D-fructose 1,6-bisphosphate	-	Saccharomyces cerevisiae
4.1.2.13	20	-	D-fructose 1,6-bisphosphate	-	Helicobacter pylori

Organism

EC Number	Organism	UniProt	Comment	Textmining
4.1.2.13	Helicobacter pylori	P56109	-	-
4.1.2.13	Oryctolagus cuniculus	P00883	-	-
4.1.2.13	Saccharomyces cerevisiae	P14540	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
4.1.2.13	muscle	-	Oryctolagus cuniculus	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
4.1.2.13	D-fructose 1,6-bisphosphate	-	Oryctolagus cuniculus	glycerone phosphate + D-glyceraldehyde 3-phosphate	-	?
4.1.2.13	D-fructose 1,6-bisphosphate	-	Helicobacter pylori	glycerone phosphate + D-glyceraldehyde 3-phosphate	-	?
4.1.2.13	D-fructose-1,6-bisphosphate	-	Saccharomyces cerevisiae	dihydroxyacetone phosphate + glyceraldehyde-3-phosphate	-	?

Synonyms

EC Number	Synonyms	Comment	Organism
4.1.2.13	class I Fba	-	Oryctolagus cuniculus
4.1.2.13	class I muscle fructose bis-phosphate aldolase	-	Oryctolagus cuniculus
4.1.2.13	class II aldolase	-	Saccharomyces cerevisiae
4.1.2.13	class II aldolase	-	Helicobacter pylori
4.1.2.13	FBA	-	Oryctolagus cuniculus
4.1.2.13	FBA	-	Saccharomyces cerevisiae
4.1.2.13	FBA	-	Helicobacter pylori
4.1.2.13	fructose bis-phosphate aldolase	-	Oryctolagus cuniculus
4.1.2.13	fructose bis-phosphate aldolase	-	Saccharomyces cerevisiae
4.1.2.13	fructose bis-phosphate aldolase	-	Helicobacter pylori

Ki Value [mM]

EC Number	Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
4.1.2.13	0.0073	-	D-mannitol 1,6-bisphosphate	-	Oryctolagus cuniculus
4.1.2.13	0.06	-	D-glucitol 1,6-bisphosphate	-	Saccharomyces cerevisiae
4.1.2.13	0.073	-	D-mannitol 1,6-bisphosphate	-	Helicobacter pylori
4.1.2.13	0.1	-	D-glucitol 1,6-bisphosphate	-	Oryctolagus cuniculus
4.1.2.13	0.17	-	D-glucitol 1,6-bisphosphate	-	Helicobacter pylori
4.1.2.13	0.4	-	D-mannitol 1,6-bisphosphate	-	Saccharomyces cerevisiae

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Release 2023.1 (January 2023)