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Literature summary extracted from

  • Wojtal, K.A.; Hoekstra, D.; van Ijzendoorn, S.C.
    cAMP-dependent protein kinase A and the dynamics of epithelial cell surface domains: moving membranes to keep in shape (2008), Bioessays, 30, 146-155.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.11.11 expressed in HEK293 cells Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.11.11 centrosome
-
 Rattus norvegicus 5813
-
2.7.11.11 cytoskeleton
-
 Rattus norvegicus 5856
-
2.7.11.11 endoplasmic reticulum
-
 Rattus norvegicus 5783
-
2.7.11.11 Golgi apparatus
-
 Rattus norvegicus 5794
-
2.7.11.11 plasma membrane
-
 Rattus norvegicus 5886
-

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.11 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.11 brain
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.11 ATP + low-density lipoprotein-related protein
-
 Rattus norvegicus ADP + phosphorylated low-density lipoprotein-related protein
-
 ?
2.7.11.11 ATP + syntaphilin
-
 Rattus norvegicus ADP + syntaphilin phosphate
-
 ?
2.7.11.11 ATP + tomosyn
-
 Rattus norvegicus ADP + tomosyn phosphate
-
 ?

Subunits

EC Number Subunits Comment Organism
2.7.11.11 tetramer consists of two regulatory and two catalytic subunits, the regulatory subunits of PKA bind to free catalytic subunits (alpha, beta, gamma, or PRkX) and their primary function appears to keep the catalytic subunits in an inactive state, two molecules of cAMP bind to each regulatory subunit of PKA and causes the subsequent release and activation of the catalytic subunits Rattus norvegicus

Synonyms

EC Number Synonyms Comment Organism
2.7.11.11 PKA
-
 Rattus norvegicus
2.7.11.11 protein kinase A
-
 Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.11.11 ATP
-
 Rattus norvegicus
2.7.11.11 cAMP dependent Rattus norvegicus