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Literature summary extracted from

  • Li, Z.; Hailemariam, T.K.; Zhou, H.; Li, Y.; Duckworth, D.C.; Peake, D.A.; Zhang, Y.; Kuo, M.S.; Cao, G.; Jiang, X.C.
    Inhibition of sphingomyelin synthase (SMS) affects intracellular sphingomyelin accumulation and plasma membrane lipid organization (2007), Biochim. Biophys. Acta, 1771, 1186-1194.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.8.27 SMS1 and SMS2 expression levels, quatitative determination by Real-time PCT analysis, overview Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
2.7.8.27 additional information downregulation of SMS in Huh7 cells by expression of siRNA, overview Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.8.27 potassium tricyclodecan-9-yl-xanthogenate i.e. D609, decreases enzyme activity an sphingomyelin levels in different human cell lines in vivo Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.8.27 plasma membrane
-
 Homo sapiens 5886
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.8.27 additional information Homo sapiens sphingomyelin plays a very important role both in cell membrane formation, inhibition of sphingomyelin synthase affects intracellular sphingomyelin accumulation and plasma membrane lipid organization, overview ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.8.27 Homo sapiens
-
 isozymes SMS1 and SMS2
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.8.27 HEK-293 cell
-
 Homo sapiens
-
2.7.8.27 Hep-G2 cell
-
 Homo sapiens
-
2.7.8.27 Huh-7 cell a hepatoma cell line Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.8.27 L-alpha-phosphatidylcholine + N-(6-[(7-nitro-benz-2-oxa-1,3-diazo-4-yl)amino]caproyl)-ceramide i.e. NBD-C6-ceramide Homo sapiens ?
-
 ?
2.7.8.27 additional information sphingomyelin plays a very important role both in cell membrane formation, inhibition of sphingomyelin synthase affects intracellular sphingomyelin accumulation and plasma membrane lipid organization, overview Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.8.27 SMS1
-
 Homo sapiens
2.7.8.27 SMS2
-
 Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.7.8.27 37
-
 assay at Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.7.8.27 7.4
-
 assay at Homo sapiens