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Literature summary extracted from
- Valproic acid metabolites inhibit dihydrolipoyl dehydrogenase activity leading to impaired 2-oxoglutarate-driven oxidative phosphorylation (2007), Biochim. Biophys. Acta, 1767, 1126-1133.
Application
| EC Number | Application | Comment | Organism |
|---|---|---|---|
| 1.8.1.4 | degradation | decreased activity of DLDH induced by valproic acid metabolites may, at least in part, account for the impaired rate of oxygen consumption and ATP synthesis in mitochondria if 2-oxoglutarate or glutamate are used as respiratory substrates, thus limiting the flux of these substrates through the citric acid cycle | Rattus norvegicus |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.8.1.4 | valproyl-CoA | competitive inhibitor, 0.5-1.0 mM inhibit DLDH activity | Rattus norvegicus |  |
| 1.8.1.4 | valproyl-dephosphoCoA | uncompetitive inhibitor, 0.5-1.0 mM inhibit DLDH activity | Rattus norvegicus | |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 1.8.1.4 | mitochondrion | - |
Rattus norvegicus | 5739 | - |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.8.1.4 | Rattus norvegicus | - |
male Wistar rats | - |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 1.8.1.4 | hepatocyte | - |
Rattus norvegicus | - |
| 1.8.1.4 | liver | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.8.1.4 | dihydrolipoamide + NAD+ | - |
Rattus norvegicus | lipoamide + NADH | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 1.8.1.4 | dihydrolipoamide dehydrogenase | - |
Rattus norvegicus |
| 1.8.1.4 | DLDH | - |
Rattus norvegicus |
| 1.8.1.4 | E3 | - |
Rattus norvegicus |
Ki Value [mM]
| EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 1.8.1.4 | 1.43 | - |
valproyl-CoA | - |
Rattus norvegicus | |
| 1.8.1.4 | 1.6 | - |
valproyl-dephosphoCoA | - |
Rattus norvegicus | |
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Release 2023.1 (January 2023)
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