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Literature summary extracted from

  • Williams, L.; Fan, F.; Blanchard, J.S.; Raushel, F.M.
    Positional isotope exchange analysis of the Mycobacterium smegmatis cysteine ligase (MshC) (2008), Biochemistry, 47, 4843-4850.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6.3.1.13 1-O-(2-amino-2-deoxy-alpha-D-glucopyranosyl)-1D-myo-inositol + L-cysteine + ATP Mycolicibacterium smegmatis the product 1D-myo-inositol 2-(L-cysteinyl)amido-2-deoxy-alpha-D-glucopyranoside is an intermediate in the biosynthetic pathway of mycothiol. Mycothiol is produced by Mycobacterium tuberculosis to maintain an intracellular reducing environment and protect against oxidative and antibiotic induced stress. The biosynthesis of mycothiol is essential for cell growth 1-O-[2-(L-cysteinamido)-2-deoxy-alpha-D-glucopyranosyl]-1D-myo-inositol + AMP + diphosphate
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Organism

EC Number Organism UniProt Comment Textmining
6.3.1.13 Mycolicibacterium smegmatis
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.3.1.13 1-O-(2-amino-2-deoxy-alpha-D-glucopyranosyl)-1D-myo-inositol + L-cysteine + ATP the product 1D-myo-inositol 2-(L-cysteinyl)amido-2-deoxy-alpha-D-glucopyranoside is an intermediate in the biosynthetic pathway of mycothiol. Mycothiol is produced by Mycobacterium tuberculosis to maintain an intracellular reducing environment and protect against oxidative and antibiotic induced stress. The biosynthesis of mycothiol is essential for cell growth Mycolicibacterium smegmatis 1-O-[2-(L-cysteinamido)-2-deoxy-alpha-D-glucopyranosyl]-1D-myo-inositol + AMP + diphosphate
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6.3.1.13 1-O-(2-amino-2-deoxy-alpha-D-glucopyranosyl)-1D-myo-inositol + L-cysteine + ATP positional isotope exchange analysis confirms that MshC catalyzes the formation of a kinetically competent cysteinyl-adenylate intermediate after the addition of ATP and cysteine Mycolicibacterium smegmatis 1-O-[2-(L-cysteinamido)-2-deoxy-alpha-D-glucopyranosyl]-1D-myo-inositol + AMP + diphosphate
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Synonyms

EC Number Synonyms Comment Organism
6.3.1.13 MshC
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 Mycolicibacterium smegmatis