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Literature summary extracted from

  • Bosis, E.; Nachliel, E.; Cohen, T.; Takeda, Y.; Ito, Y.; Bar-Nun, S.; Gutman, M.
    Endoplasmic Reticulum Glucosidase II is inhibited by its end products (2008), Biochemistry, 47, 10970-10980.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.2.1.207 calreticulin 75 micromol, conversion of Glc2Man7-residue to Glc1Man7-residue Rattus norvegicus
3.2.1.207 calreticulin in higher concentrations faster hydrolysis of Glc2Man9-residue Rattus norvegicus
3.2.1.207 GlcMan9GlcNAc2 faster reaction Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.2.1.207 calreticulin slower hydrolysis of Glc1Man9-residue to Glc0Man9-residue Rattus norvegicus
3.2.1.207 Man7GlcNAc2
-
 Rattus norvegicus
3.2.1.207 Man9GlcNAc2
-
 Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.2.1.207 0.49
-
 N-[[2-carboxy-5-(4-methoxyphenyl)thiophen-3-yl]carbamoyl]-L-tyrosine Glc2Man7GlcNAc2 Rattus norvegicus
3.2.1.207 15 23 N-[[2-carboxy-5-(4-methoxyphenyl)thiophen-3-yl]carbamoyl]-L-tyrosine Glc2Man9GlcNAc2 Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.2.1.207 endoplasmic reticulum
-
 Rattus norvegicus 5783
-

Organism

EC Number Organism UniProt Comment Textmining
3.2.1.207 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.2.1.207 liver
-
 Rattus norvegicus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.2.1.207 0.08
-
 measured with substrate p-nitrophenyl-alpha-D-pyranosile Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.2.1.207 Glc2Man7GlcNAc2 + H2O
-
 Rattus norvegicus GlcMan7GlcNAc2 + D-glucose
-
 ?
3.2.1.207 Glc2Man9GlcNAc2 + H2O
-
 Rattus norvegicus GlcMan9GlcNAc2 + D-glucose
-
 ?
3.2.1.207 GlcMan7GlcNAc2 + H2O
-
 Rattus norvegicus Man7GlcNAc2 + D-glucose
-
 ?
3.2.1.207 GlcMan9GlcNAc2 + H2O
-
 Rattus norvegicus Man9GlcNAc2 + D-glucose
-
 ?
3.2.1.207 additional information kinetic model for the interaction of glucosidase with calnexin/calreticulin Rattus norvegicus ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.2.1.207 endoplasmic reticulum glucosidase II
-
 Rattus norvegicus
3.2.1.207 glucosidase II
-
 Rattus norvegicus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.2.1.207 37
-
 incubation time is 10 min Rattus norvegicus

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
3.2.1.207 4
-
-
 Rattus norvegicus Man7GlcNAc2
3.2.1.207 40
-
-
 Rattus norvegicus Man9GlcNAc2