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Literature summary extracted from

  • Murayama, K.; Kato-Murayama, M.; Mishima, C.; Akasaka, R.; Shirouzu, M.; Fukui, Y.; Yokoyama, S.
    Crystal structure of the Brutons tyrosine kinase PH domain with phosphatidylinositol (2008), Biochem. Biophys. Res. Commun., 377, 23-28.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.10.2 the Btk PH domain is expressed in Spodoptera frugiperda Sf9 insect cells using the baculovirus expression system Homo sapiens

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
2.7.10.2 the crystal structure of a Btk fragment consisting of the PH domain and the Btk motif in complex with dibutylyl-phosphatidylinositol-3,4,5-triphosphate is determined Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.10.2 plasma membrane
-
 Homo sapiens 5886
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.10.2 Zn2+
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.10.2 ATP + [protein]-L-tyrosine Homo sapiens
-
 ADP + [protein]-L-tyrosine phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.10.2 Homo sapiens Q06187
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.7.10.2 using a HiTrap SP, a Mono S, and a HiLoad Superdex75 column Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.10.2 ATP + [protein]-L-tyrosine
-
 Homo sapiens ADP + [protein]-L-tyrosine phosphate
-
 ?

Subunits

EC Number Subunits Comment Organism
2.7.10.2 homodimer the Btk PH domain forms a homodimer Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
2.7.10.2 Bruton's tyrosine kinase
-
 Homo sapiens
2.7.10.2 Bruton's tyrosine kinase PH domain
-
 Homo sapiens
2.7.10.2 Btk
-
 Homo sapiens