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Literature summary extracted from

  • Hassan, G.S.; Farag, N.A.; Hegazy, G.H.; Arafa, R.K.
    Design and synthesis of novel benzopyran-2-one derivatives of expected antimicrobial activity through DNA gyrase-B inhibition (2008), Arch. Pharm., 341, 725-733.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
5.6.2.2 1-(4-nitrobenzylidene)-2-(2-oxo-4-phenyl-2H-benzo[b]pyran-7-yloxy)acetohydrazide
-
 Bacillus subtilis
5.6.2.2 1-(4-nitrobenzylidene)-2-(2-oxo-4-phenyl-2H-benzo[b]pyran-7-yloxy)acetohydrazide
-
 Candida albicans
5.6.2.2 1-(4-nitrobenzylidene)-2-(2-oxo-4-phenyl-2H-benzo[b]pyran-7-yloxy)acetohydrazide
-
 Escherichia coli
5.6.2.2 1-(4-nitrobenzylidene)-2-(2-oxo-4-phenyl-2H-benzo[b]pyran-7-yloxy)acetohydrazide
-
 Staphylococcus aureus
5.6.2.2 1-(benzylidene)-2-(2-oxo-4-phenyl-2H-benzo[b]pyran-7-yloxy)acetohydrazide
-
 Bacillus subtilis
5.6.2.2 2-(furan-2-yl)-3-[2-oxo-4-phenyl-2H-benzo[b]pyran-7-yloxyacetamido]-thiazolidin-4-one
-
 Bacillus subtilis
5.6.2.2 2-(furan-2-yl)-3-[2-oxo-4-phenyl-2H-benzo[b]pyran-7-yloxyacetamido]-thiazolidin-4-one
-
 Escherichia coli
5.6.2.2 3-acetyl-2-(4-methoxyphenyl)-5-(2-oxo-4-phenyl-2H-benzo[b]pyran-7-yloxymethyl)-1,3,4-(2H)-oxadiazole
-
 Staphylococcus aureus
5.6.2.2 3-chloro-4-(4-nitrophenyl)-1-[(2-oxo-4-phenyl-2H-benzo[b]pyran-7-yloxy)acetamido] azetidin-2-one
-
 Escherichia coli
5.6.2.2 3-chloro-4-(4-nitrophenyl)-1-[(2-oxo-4-phenyl-2H-benzo[b]pyran-7-yloxy)acetamido] azetidin-2-one
-
 Staphylococcus aureus
5.6.2.2 3-chloro-4-phenyl-1-[(2-oxo-4-phenyl-2H-benzo[b]pyran-7-yloxy)acetamido]azetidin-2-one
-
 Bacillus subtilis
5.6.2.2 4-chloro-5-(4-nitrophenyl)-1-[(2-oxo-4-phenyl-2H-benzo[b]pyran-7-yloxy)acetamido] pyrrolidin-2-one
-
 Bacillus subtilis
5.6.2.2 4-chloro-5-phenyl-1-[(2-oxo-4-phenyl-2H-benzo[b]pyran-7-yloxy)acetamido]pyrrolidin-2-one
-
 Staphylococcus aureus
5.6.2.2 Amphotericin B
-
 Candida albicans
5.6.2.2 additional information not inhibited by 3-chloro-4-(4-nitrophenyl)-1-[(2-oxo-4-phenyl-2H-benzo[b]pyran-7-yloxy)acetamido] azetidin-2-one, 4-chloro-5-phenyl-1-[(2-oxo-4-phenyl-2H-benzo[b]pyran-7-yloxy)acetamido]pyrrolidin-2-one, 4-chloro-5-(4-chlorophenyl)-1-[(2-oxo-4-phenyl-2H-benzo[b]pyran-7-yloxy)acetamido] pyrrolidin-2-one, 3-acetyl-2-(furan-2-yl)-5-(2-oxo-4-phenyl-2H-benzo[b]pyran-7-yloxymethyl)-1,3,4-(2H)-oxadiazole, 3-acetyl-2-(4-methoxyphenyl)-5-(2-oxo-4-phenyl-2H-benzo[b]pyran-7-yloxymethyl)-1,3,4-(2H)-oxadiazole, and amphotericin B Bacillus subtilis
5.6.2.2 additional information not inhibited by 1-(benzylidene)-2-(2-oxo-4-phenyl-2H-benzo[b]pyran-7-yloxy)acetohydrazide, 3-chloro-4-phenyl-1-[(2-oxo-4-phenyl-2H-benzo[b]pyran-7-yloxy)acetamido]azetidin-2-one, 3-chloro-4-(4-nitrophenyl)-1-[(2-oxo-4-phenyl-2H-benzo[b]pyran-7-yloxy)acetamido] azetidin-2-one, 4-chloro-5-(furan-2-yl)-1-[(2-oxo-4-phenyl-2H-benzo[b]pyran-7-yloxy)acetamido] pyrrolidin-2-one, 4-chloro-5-phenyl-1-[(2-oxo-4-phenyl-2H-benzo[b]pyran-7-yloxy)acetamido]pyrrolidin-2-one, 4-chloro-5-(4-chlorophenyl)-1-[(2-oxo-4-phenyl-2H-benzo[b]pyran-7-yloxy)acetamido] pyrrolidin-2-one, 4-chloro-5-(4-nitrophenyl)-1-[(2-oxo-4-phenyl-2H-benzo[b]pyran-7-yloxy)acetamido] pyrrolidin-2-one, 3-acetyl-2-(furan-2-yl)-5-(2-oxo-4-phenyl-2H-benzo[b]pyran-7-yloxymethyl)-1,3,4-(2H)-oxadiazole, 3-acetyl-2-(4-methoxyphenyl)-5-(2-oxo-4-phenyl-2H-benzo[b]pyran-7-yloxymethyl)-1,3,4-(2H)-oxadiazole, 2-(furan-2-yl)-3-[2-oxo-4-phenyl-2H-benzo[b]pyran-7-yloxyacetamido]-thiazolidin-4-one, and tetracycline Candida albicans
5.6.2.2 additional information not inhibited by 1-(benzylidene)-2-(2-oxo-4-phenyl-2H-benzo[b]pyran-7-yloxy)acetohydrazide, 3-chloro-4-phenyl-1-[(2-oxo-4-phenyl-2H-benzo[b]pyran-7-yloxy)acetamido]azetidin-2-one, 4-chloro-5-(furan-2-yl)-1-[(2-oxo-4-phenyl-2H-benzo[b]pyran-7-yloxy)acetamido] pyrrolidin-2-one 4a4-chloro-5-phenyl-1-[(2-oxo-4-phenyl-2H-benzo[b]pyran-7-yloxy)acetamido]pyrrolidin-2-one, 4-chloro-5-(4-chlorophenyl)-1-[(2-oxo-4-phenyl-2H-benzo[b]pyran-7-yloxy)acetamido] pyrrolidin-2-one, 4-chloro-5-(4-nitrophenyl)-1-[(2-oxo-4-phenyl-2H-benzo[b]pyran-7-yloxy)acetamido] pyrrolidin-2-one, 3-acetyl-2-(furan-2-yl)-5-(2-oxo-4-phenyl-2H-benzo[b]pyran-7-yloxymethyl)-1,3,4-(2H)-oxadiazole, 3-acetyl-2-(4-methoxyphenyl)-5-(2-oxo-4-phenyl-2H-benzo[b]pyran-7-yloxymethyl)-1,3,4-(2H)-oxadiazole, and amphotericin B Escherichia coli
5.6.2.2 additional information not inhibited by 1-(benzylidene)-2-(2-oxo-4-phenyl-2H-benzo[b]pyran-7-yloxy)acetohydrazide, 3-chloro-4-phenyl-1-[(2-oxo-4-phenyl-2H-benzo[b]pyran-7-yloxy)acetamido]azetidin-2-one, 4-chloro-5-(4-chlorophenyl)-1-[(2-oxo-4-phenyl-2H-benzo[b]pyran-7-yloxy)acetamido] pyrrolidin-2-one, 4-chloro-5-(4-nitrophenyl)-1-[(2-oxo-4-phenyl-2H-benzo[b]pyran-7-yloxy)acetamido] pyrrolidin-2-one, 3-acetyl-2-(furan-2-yl)-5-(2-oxo-4-phenyl-2H-benzo[b]pyran-7-yloxymethyl)-1,3,4-(2H)-oxadiazole, 2-(furan-2-yl)-3-[2-oxo-4-phenyl-2H-benzo[b]pyran-7-yloxyacetamido]-thiazolidin-4-one, and amphotericin B Staphylococcus aureus
5.6.2.2 tetracycline
-
 Bacillus subtilis
5.6.2.2 tetracycline
-
 Escherichia coli
5.6.2.2 tetracycline
-
 Staphylococcus aureus
5.6.2.2 y, Namen korrigieren: 4-chloro-5-(furan-2-yl)-1-[(2-oxo-4-phenyl-2H-benzo[b]pyran-7-yloxy)acetamido]pyrrolidin-2-one
-
 Bacillus subtilis
5.6.2.2 y, Namen korrigieren: 4-chloro-5-(furan-2-yl)-1-[(2-oxo-4-phenyl-2H-benzo[b]pyran-7-yloxy)acetamido]pyrrolidin-2-one
-
 Staphylococcus aureus

Organism

EC Number Organism UniProt Comment Textmining
5.6.2.2 Bacillus subtilis
-
-
-
5.6.2.2 Candida albicans
-
-
-
5.6.2.2 Escherichia coli P0AES6
-
-
5.6.2.2 Micrococcus luteus
-
-
-
5.6.2.2 Staphylococcus aureus
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5.6.2.2 supercoiled DNA + ATP + H2O
-
 Staphylococcus aureus catenated DNA networks + ADP + phosphate
-
 ?
5.6.2.2 supercoiled DNA + ATP + H2O
-
 Bacillus subtilis catenated DNA networks + ADP + phosphate
-
 ?
5.6.2.2 supercoiled DNA + ATP + H2O
-
 Micrococcus luteus catenated DNA networks + ADP + phosphate
-
 ?
5.6.2.2 supercoiled DNA + ATP + H2O
-
 Candida albicans catenated DNA networks + ADP + phosphate
-
 ?
5.6.2.2 supercoiled DNA + ATP + H2O
-
 Escherichia coli catenated DNA networks + ADP + phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
5.6.2.2 DNA gyrase-B
-
 Staphylococcus aureus
5.6.2.2 DNA gyrase-B
-
 Bacillus subtilis
5.6.2.2 DNA gyrase-B
-
 Micrococcus luteus
5.6.2.2 DNA gyrase-B
-
 Candida albicans
5.6.2.2 DNA gyrase-B
-
 Escherichia coli

Cofactor

EC Number Cofactor Comment Organism Structure
5.6.2.2 ATP
-
 Staphylococcus aureus
5.6.2.2 ATP
-
 Bacillus subtilis
5.6.2.2 ATP
-
 Micrococcus luteus
5.6.2.2 ATP
-
 Candida albicans
5.6.2.2 ATP
-
 Escherichia coli