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Literature summary extracted from

  • Kumagai, T.; Nangaku, M.; Inagi, R.
    Pathophysiological role of the glyoxalase system in renal hypoxic injury (2008), Ann. N. Y. Acad. Sci., 1126, 265-267.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
4.4.1.5 rats, overexpressing human GLO I show e.g. improvement of the tubulointerstitial injury and renal function Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.4.1.5 additional information Rattus norvegicus the glyoxalase system detoxifies methylglyoxal and is composed of two enzymes: glyoxylase I (GLO I), which metabolizes methylglyoxal to S-D-lactoylglutathione, and glyoxalase II (GLO II, EC 3.1.2.6) which converts S-D-lactoylglutathione to D-lactate ?
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 ?

Organism

EC Number Organism UniProt Comment Textmining
4.4.1.5 Rattus norvegicus
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Reaction

EC Number Reaction Comment Organism Reaction ID
4.4.1.5 (R)-S-lactoylglutathione = glutathione + 2-oxopropanal investigation of the biological role of GLO I in renal hypoxic diseases by using the rat ischemia/reperfusion (I/R) injury model. I/R induces the reduction of renal GLO I activity associated with morphological changes and renal dysfunction Rattus norvegicus
a

Source Tissue

EC Number Source Tissue Comment Organism Textmining
4.4.1.5 additional information ischemia/reperfusion induces the reduction of GLO I activity in the kidney, which is asssociated with morphological damage and renal dysfunction Rattus norvegicus
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Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
4.4.1.5 additional information
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 ischemia/reperfusion induces the reduction of GLO I activity in the kidney, which is asssociated with morphological damage and renal dysfunction Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.4.1.5 glutathione + methylglyoxal methylglyoxal is a reactive dicarbonyl compound mainly produced by metabolic pathways such as glycolysis, binds to proteins or nucelic acids and forms advanced glycation end products Rattus norvegicus S-((R)-lactoyl)glutathione
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 ?
4.4.1.5 additional information the glyoxalase system detoxifies methylglyoxal and is composed of two enzymes: glyoxylase I (GLO I), which metabolizes methylglyoxal to S-D-lactoylglutathione, and glyoxalase II (GLO II, EC 3.1.2.6) which converts S-D-lactoylglutathione to D-lactate Rattus norvegicus ?
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 ?