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Literature summary extracted from

  • Said, M.; Becerra, R.; Palomeque, J.; Rinaldi, G.; Kaetzel, M.A.; Diaz-Sylvester, P.L.; Copello, J.A.; Dedman, J.R.; Mundina-Weilenmann, C.; Vittone, L.; Mattiazzi, A.
    Increased intracellular Ca2+ and SR Ca2+ load contribute to arrhythmias after acidosis in rat heart. Role of Ca2+/calmodulin-dependent protein kinase II (2008), Am. J. Physiol. Heart Circ. Physiol., 295, H1669-H1683.
    View publication on PubMedView publication on EuropePMC

Application

EC Number Application Comment Organism
2.7.11.17 medicine arrhythmia is favored by CamKII activation during acidosis Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.11.17 KN-93 0.001 mM Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.11.17 Ca2+ dependent on Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.17 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.17 heart
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.17 ATP + phospholamban
-
 Rattus norvegicus ADP + phosphorylated phospholamban
-
 ?
2.7.11.17 ATP + ryanodine receptor type 2
-
 Rattus norvegicus ADP + phosphorylated ryanodine receptor type 2
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.11.17 Ca2+/calmodulin-dependent protein kinase II
-
 Rattus norvegicus
2.7.11.17 CaMKII
-
 Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.11.17 ATP
-
 Rattus norvegicus
2.7.11.17 Calmodulin dependent on Rattus norvegicus