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Literature summary extracted from

  • Mukoyoshi, M.; Nishimura, S.; Hoshide, S.; Umeda, S.; Kanou, M.; Taniguchi, K.; Muroga, H.
    In vitro drug-drug interaction studies with febuxostat, a novel non-purine selective inhibitor of xanthine oxidase: plasma protein binding, identification of metabolic enzymes and cytochrome P450 inhibition (2008), Xenobiotica, 38, 496-510.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.17.3.2 febuxostat i.e. 2-[3-cyano-4-(2-methylpropoxy)phenyl]-4-methylthiazole-5-carboxylic acid, a non-purine selective inhibitor of xanthine oxidase, an anti-hyperuricaemia drug with low drug-drug interaction potential in clinical use, in vitro drug-drug interaction studies, using ibuprofen, verapamil, nitrendipine, captopril, bezafibrate, warfarin, and digoxin. Febuxostat does not influence the plasma protein binding, and the presence of ibuprofen or warfarin does not change the plasma protein binding of febuxostat of ibuprofen or warfarin, overview Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.17.3.2 xanthine + H2O + O2 Homo sapiens
-
urate + H2O2
-
?

Organism

EC Number Organism UniProt Comment Textmining
1.17.3.2 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.17.3.2 xanthine + H2O + O2
-
Homo sapiens urate + H2O2
-
?