Literature summary extracted from

Wu, S.C.; Hong, W.W.; Liu, J.H.
Short hairpin RNA targeted to dihydrofolate reductase enhances the immunoglobulin G expression in gene-amplified stable Chinese hamster ovary cells (2008), Vaccine, 26, 4969-4974.

Application

EC Number	Application	Comment	Organism
1.5.1.3	synthesis	the use of the dihydrofolate-reductase-targeted short hairpin RNA vector can enhance the IgG expression in the gene-amplified stable CHO cells and uphold the IgG expression in methotrexate-free cultures	Cricetulus griseus

Protein Variants

EC Number	Protein Variants	Comment	Organism
1.5.1.3	additional information	use of the dihydrofolate reductase-targeted short hairpin RNA vector for immunoglobulin G expression in geneamplified stable CHO cells. Cells increase IgG expression at 1.0 microM methotrexate by more than 100% and improve the genomic stability of IgG expression in methotrexate-free cultures by approximately 30%	Cricetulus griseus

Organism

EC Number	Organism	UniProt	Comment	Textmining
1.5.1.3	Cricetulus griseus	-	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining

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Release 2023.1 (January 2023)