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Literature summary extracted from

  • Dufernez, F.; Derelle, E.; Noel, C.; Sanciu, G.; Mantini, C.; Dive, D.; Soyer-Gobillard, M.O.; Capron, M.; Pierce, R.J.; Wintjens, R.; Guillebault, D.; Viscogliosi, E.
    Molecular characterization of iron-containing superoxide dismutases in the heterotrophic dinoflagellate Crypthecodinium cohnii (2008), Protist, 159, 223-238.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.15.1.1 molecular heterogeneity of the enzyme in Crypthecodinium cohnii at both genomic and transcriptional levels, DNA and amino acid sequence determination and analysis of genes sod1-sod17, phylogenetic analysis, the Crypthecodinium cohnii SODs form a monophyletic group and are all acquired by the same event of horizontal gene transfer, functional overexpression of sod1 in Escherichia coli Crypthecodinium cohnii

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.15.1.1 H2O2 inactivation of FeSOD; inactivation of FeSOD; inactivation of FeSOD Crypthecodinium cohnii
1.15.1.1 additional information no inhibition by CN; no inhibition by CN; no inhibition by CN Crypthecodinium cohnii

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.15.1.1 cytoplasm determined from amino acid sequence and structure analysis Crypthecodinium cohnii 5737
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.15.1.1 Fe2+ all isozymes in the organism are FeSODs Crypthecodinium cohnii
1.15.1.1 additional information no MnSOD and Cu/ZnSOD in Crypthecodinium cohnii Crypthecodinium cohnii

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.15.1.1 23652
-
 2 * 23652, SOD1, sequence calculation Crypthecodinium cohnii

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.15.1.1 O2.- + H+ Crypthecodinium cohnii a metalloenzyme that eliminates superoxide radicals by dismutation into hydrogen peroxide and molecular oxygen O2 + H2O2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.15.1.1 Crypthecodinium cohnii B0L421 ATCC 50050, a heterotrophic dinoflagellate, a multi-copy gene family comprising genes sod1-sod17 encoding FeSODs
-
1.15.1.1 Crypthecodinium cohnii B2KYC6 FeSOD fragment; ATCC 50050, a heterotrophic dinoflagellate, a multi-copy gene family comprising genes sod1-sod17 encoding FeSODs
-
1.15.1.1 Crypthecodinium cohnii B2KYC9 FeSOD fragment; ATCC 50050, a heterotrophic dinoflagellate, a multi-copy gene family comprising genes sod1-sod17 encoding FeSODs
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.15.1.1 O2.- + H+
-
 Crypthecodinium cohnii O2 + H2O2
-
 ?
1.15.1.1 O2.- + H+ a metalloenzyme that eliminates superoxide radicals by dismutation into hydrogen peroxide and molecular oxygen Crypthecodinium cohnii O2 + H2O2
-
 ?

Subunits

EC Number Subunits Comment Organism
1.15.1.1 dimer 2 * 23652, SOD1, sequence calculation Crypthecodinium cohnii
1.15.1.1 More SOD1 possesses a short amino-terminal extension which could represent, in this heterotrophic dinoflagellate lacking a chloroplast, a putative mitochondrial targeting signal Crypthecodinium cohnii

Synonyms

EC Number Synonyms Comment Organism
1.15.1.1 FeSOD
-
 Crypthecodinium cohnii
1.15.1.1 iron-containing superoxide dismutase
-
 Crypthecodinium cohnii
1.15.1.1 SOD
-
 Crypthecodinium cohnii

pI Value

EC Number Organism Comment pI Value Maximum pI Value
1.15.1.1 Crypthecodinium cohnii SOD1, sequence calculation
-
 5.31