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Literature summary extracted from

  • Hetman, J.M.; Soderling, S.H.; Glavas, N.A.; Beavo, J.A.
    Cloning and characterization of PDE7B, a cAMP-specific phosphodiesterase (2000), Proc. Natl. Acad. Sci. USA, 97, 472-476.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.1.4.53 PDE7B protein is expressed in a baculovirus expression system Mus musculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.4.53 3-isobutyl-1-methylxanthine
-
 Mus musculus
3.1.4.53 dipyridamole
-
 Mus musculus
3.1.4.53 erythro-9-[3-(2-hydroxynonyl)]-adenine
-
 Mus musculus
3.1.4.53 papaverine
-
 Mus musculus
3.1.4.53 rolipram
-
 Mus musculus
3.1.4.53 SCH51866
-
 Mus musculus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.1.4.53 0.00003
-
 adenosine 3',5'-cyclic phosphate
-
 Mus musculus
3.1.4.53 0.0001
-
 adenosine 3',5'-cyclic phosphate PDE7A2 Mus musculus
3.1.4.53 0.0002
-
 adenosine 3',5'-cyclic phosphate PDE7A1 Mus musculus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.1.4.53 50000
-
 x * 50000, PDE7A2, calculated from sequence Mus musculus
3.1.4.53 50100
-
 x * 50100, calculated from sequence Mus musculus
3.1.4.53 57000
-
 x * 57000, PDE7A1, calculated from sequence Mus musculus

Organism

EC Number Organism UniProt Comment Textmining
3.1.4.53 Mus musculus P70453
-
-
3.1.4.53 Mus musculus Q9QXQ1
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.4.53 brain
-
 Mus musculus
-
3.1.4.53 brain PDE7A1 Mus musculus
-
3.1.4.53 epididymis
-
 Mus musculus
-
3.1.4.53 eye
-
 Mus musculus
-
3.1.4.53 heart
-
 Mus musculus
-
3.1.4.53 heart PDE7A2 Mus musculus
-
3.1.4.53 kidney PDE7A1 Mus musculus
-
3.1.4.53 liver
-
 Mus musculus
-
3.1.4.53 lung PDE7A1 Mus musculus
-
3.1.4.53 lymphoid tissue PDE7A1 Mus musculus
-
3.1.4.53 ovary
-
 Mus musculus
-
3.1.4.53 pancreas most highly expressed in pancreas followed by brain, heart, thyroid, skeletal muscle, eye, ovary, submaxillary gland, epididymus, and liver Mus musculus
-
3.1.4.53 pancreas PDE7A1 Mus musculus
-
3.1.4.53 placenta PDE7A1 Mus musculus
-
3.1.4.53 skeletal muscle
-
 Mus musculus
-
3.1.4.53 skeletal muscle PDE7A2 Mus musculus
-
3.1.4.53 submandibular gland
-
 Mus musculus
-
3.1.4.53 thyroid gland
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.4.53 adenosine 3',5'-cyclic phosphate + H2O no activity with cGMP Mus musculus adenosine 5'-phosphate
-
 ?

Subunits

EC Number Subunits Comment Organism
3.1.4.53 ? x * 50000, PDE7A2, calculated from sequence Mus musculus
3.1.4.53 ? x * 50100, calculated from sequence Mus musculus
3.1.4.53 ? x * 57000, PDE7A1, calculated from sequence Mus musculus

Synonyms

EC Number Synonyms Comment Organism
3.1.4.53 PDE7B
-
 Mus musculus

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
3.1.4.53 0.0021
-
-
 Mus musculus 3-isobutyl-1-methylxanthine
3.1.4.53 0.0045
-
-
 Mus musculus 3-isobutyl-1-methylxanthine
3.1.4.53 0.009
-
-
 Mus musculus dipyridamole
3.1.4.53 0.0125
-
-
 Mus musculus papaverine
3.1.4.53 0.022
-
-
 Mus musculus papaverine
3.1.4.53 0.035
-
-
 Mus musculus SCH51866
3.1.4.53 0.042
-
-
 Mus musculus dipyridamole
3.1.4.53 0.044
-
-
 Mus musculus SCH51866
3.1.4.53 0.13
-
-
 Mus musculus erythro-9-[3-(2-hydroxynonyl)]-adenine
3.1.4.53 0.18
-
-
 Mus musculus rolipram