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Literature summary extracted from

  • Soderling, S.H.; Bayuga, S.J.; Beavo, J.A.
    Cloning and characterization of a cAMP-specific cyclic nucleotide phosphodiesterase (1998), Proc. Natl. Acad. Sci. USA, 95, 8991-8996.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.1.4.53
-
 Mus musculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.4.53 dipyridamole
-
 Mus musculus
3.1.4.53 papaverine
-
 Mus musculus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.1.4.53 0.00015
-
 adenosine 3',5'-cyclic phosphate
-
 Mus musculus

Organism

EC Number Organism UniProt Comment Textmining
3.1.4.53 Mus musculus O88502
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.4.53 brain highest expression in testis, followed by eye, liver, skeletal muscle, heart, 7-day embryo, kidney, ovary, and brain in decreasing order Mus musculus
-
3.1.4.53 embryo highest expression in testis, followed by eye, liver, skeletal muscle, heart, 7-day embryo, kidney, ovary, and brain in decreasing order Mus musculus
-
3.1.4.53 eye highest expression in testis, followed by eye, liver, skeletal muscle, heart, 7-day embryo, kidney, ovary, and brain in decreasing order Mus musculus
-
3.1.4.53 heart highest expression in testis, followed by eye, liver, skeletal muscle, heart, 7-day embryo, kidney, ovary, and brain in decreasing order Mus musculus
-
3.1.4.53 kidney highest expression in testis, followed by eye, liver, skeletal muscle, heart, 7-day embryo, kidney, ovary, and brain in decreasing order Mus musculus
-
3.1.4.53 liver highest expression in testis, followed by eye, liver, skeletal muscle, heart, 7-day embryo, kidney, ovary, and brain in decreasing order Mus musculus
-
3.1.4.53 ovary highest expression in testis, followed by eye, liver, skeletal muscle, heart, 7-day embryo, kidney, ovary, and brain in decreasing order Mus musculus
-
3.1.4.53 skeletal muscle highest expression in testis, followed by eye, liver, skeletal muscle, heart, 7-day embryo, kidney, ovary, and brain in decreasing order Mus musculus
-
3.1.4.53 testis highest expression in testis, followed by eye, liver, skeletal muscle, heart, 7-day embryo, kidney, ovary, and brain in decreasing order. In testis PDE8 is expressed in the seminiferous epithelium in a stage-specific manner Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.4.53 adenosine 3',5'-cyclic phosphate + H2O PDE8 is specific for the hydrolysis of cAMP Mus musculus adenosine 5'-phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.4.53 cAMP-specific cyclic nucleotide phosphodiesterase
-
 Mus musculus
3.1.4.53 cAMP-specific PDE
-
 Mus musculus
3.1.4.53 PDE8
-
 Mus musculus

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
3.1.4.53 0.0045
-
-
 Mus musculus dipyridamole
3.1.4.53 0.174
-
-
 Mus musculus papaverine