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Literature summary extracted from

  • Mahmoud, S.S.; Croteau, R.B.
    Menthofuran regulates essential oil biosynthesis in peppermint by controlling a downstream monoterpene reductase (2003), Proc. Natl. Acad. Sci. USA, 100, 14481-14486.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.14.14.143 gene mfs, expression under control of the CaMV 35S promoter in transformed peppermint plants Mentha x piperita

Protein Variants

EC Number Protein Variants Comment Organism
1.14.14.143 additional information overexpression and cosuppression of mfs results in the respective increase or decrease in the production of menthofuran Mentha x piperita

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.3.1.81 additional information although (+)-menthofuran does not inhibit (+)-pulegone reductase activity, stem feeding with menthofuran selectively decreases enzyme transcript levels in immature leaves, thereby accounting for decreased reductase activity and increased pulegone content, overview, the flux of (+)-pulegone through pulegone reductase correlates negatively with the essential oil content of menthofuran, such that menthofuran, and pulegone increase, or decrease, in concert, overview Mentha x piperita

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.3.1.81 soluble
-
 Mentha x piperita
-
-
1.14.14.143 microsome
-
 Mentha x piperita
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.3.1.81 2 (+)-pulegone + 2 NADPH + 2 H+ Mentha x piperita regulation of pulegone metabolism involves menthofuran, the flux of (+)-pulegone through pulegone reductase correlates negatively with the essential oil content of menthofuran, such that menthofuran, and pulegone increase, or decrease, in concert, overview (-)-menthone + (+)-isomenthone + 2 NADP+
-
 ?
1.3.1.81 additional information Mentha x piperita pathways for monoterpene biosynthesis in peppermint, overview ?
-
 ?
1.14.14.143 (+)-pulegone + [reduced NADPH-hemoprotein reductase] + O2 Mentha x piperita pathways for monoterpene biosynthesis in peppermint, overview (+)-menthofuran + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
1.14.14.143 additional information Mentha x piperita regulation of pulegone metabolism involves menthofuran, the flux of (+)-pulegone through pulegone reductase correlates negatively with the essential oil content of menthofuran, such that menthofuran, and pulegone increase, or decrease, in concert, overview, although (+)-menthofuran does not inhibit (+)-pulegone reductase activity, stem feeding with menthofuran selectively decreases enzyme transcript levels in immature leaves, thereby accounting for decreased reductase activity and increased pulegone content, overview ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.3.1.81 Mentha x piperita
-
 cv. Black Mitcham
-
1.14.14.143 Mentha x piperita
-
 cv. Black Mitcham, gene mfs
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.3.1.81 leaf
-
 Mentha x piperita
-
1.14.14.143 leaf
-
 Mentha x piperita
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.3.1.81 additional information
-
 essential oil composition of wild-type peppermint Mentha x piperita

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.3.1.81 2 (+)-pulegone + 2 NADPH + 2 H+
-
 Mentha x piperita (-)-menthone + (+)-isomenthone + 2 NADP+
-
 ?
1.3.1.81 2 (+)-pulegone + 2 NADPH + 2 H+ regulation of pulegone metabolism involves menthofuran, the flux of (+)-pulegone through pulegone reductase correlates negatively with the essential oil content of menthofuran, such that menthofuran, and pulegone increase, or decrease, in concert, overview Mentha x piperita (-)-menthone + (+)-isomenthone + 2 NADP+
-
 ?
1.3.1.81 additional information pathways for monoterpene biosynthesis in peppermint, overview Mentha x piperita ?
-
 ?
1.14.14.143 (+)-pulegone + [reduced NADPH-hemoprotein reductase] + O2
-
 Mentha x piperita (+)-menthofuran + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
1.14.14.143 (+)-pulegone + [reduced NADPH-hemoprotein reductase] + O2 pathways for monoterpene biosynthesis in peppermint, overview Mentha x piperita (+)-menthofuran + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
1.14.14.143 additional information regulation of pulegone metabolism involves menthofuran, the flux of (+)-pulegone through pulegone reductase correlates negatively with the essential oil content of menthofuran, such that menthofuran, and pulegone increase, or decrease, in concert, overview, although (+)-menthofuran does not inhibit (+)-pulegone reductase activity, stem feeding with menthofuran selectively decreases enzyme transcript levels in immature leaves, thereby accounting for decreased reductase activity and increased pulegone content, overview Mentha x piperita ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.3.1.81 pulegone reductase
-
 Mentha x piperita
1.14.14.143 MFS
-
 Mentha x piperita

Cofactor

EC Number Cofactor Comment Organism Structure
1.3.1.81 NADPH
-
 Mentha x piperita