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Literature summary extracted from

  • Tijhuis, M.J.; Boerboom, A.M.; Visker, M.H.; Op den Camp, L.; Nagengast, F.M.; Tan, A.C.; Rietjens, I.M.; Kok, F.J.; Aarts, J.M.; Kampman, E.
    The influence of fruit and vegetable consumption and genetic variation on NAD(P)H:quinone oxidoreductase (NQO1) phenotype in an endoscopy-based population (2008), Nutr. Cancer, 60, 204-215.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.6.5.2 additional information vegetable consumption only is not associated with NQO1 mRNA level or NQO1 activity Homo sapiens

Application

EC Number Application Comment Organism
1.6.5.2 medicine NQO1 polymorphism analysis is performed using genomic DNA from rectal biopsy samples, genotypes of C609T, T609T and C609C, G718G, A718A and A718G polymorphisms of NQO1 are compared, C609C genotype shows higher activity, C609T polymorphism is a important predictor for rectal NQO1 activity, fruit and vegetable consumption have no influence on NQO1 activity Homo sapiens
1.6.5.2 medicine genetic variation, especially the NQO1 609CT polymorphism, is a more important predictor of rectal NQO1 phenotype than fruit and vegetable consumption. White blood cell NQO1 activity is not a good surrogate for rectal activity Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.6.5.2 additional information fruit and vegetable consumption may repress rather than induce rectal NQO1 phenotype. Consumption of Compositae is associated with lower rectal NQO1 mRNA level. Consumption of Apiaceae is associated with lower rectal NQO1 activity Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
1.6.5.2 Homo sapiens
-
 simoidoscopy patients
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1.6.5.2 Homo sapiens P15559
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.6.5.2 leukocyte
-
 Homo sapiens
-
1.6.5.2 leukocyte no correlation between NQO1 activity in rectal biopsies and NQO1 activity in total leukocytes. No correlation between total leukocyte and lymphocyte NQO1 activity Homo sapiens
-
1.6.5.2 lymphocyte no correlation between NQO1 activity in rectal biopsies and NQO1 activity in total lymphocytes. No correlation between total leukocyte and lymphocyte NQO1 activity Homo sapiens
-
1.6.5.2 rectum
-
 Homo sapiens
-
1.6.5.2 rectum rectal activity is higher among NQO1 609CC-genotypes as compared to 609CT-genotypes, whereas mRNA is higher among 609CT-genotypes. Activity and mRNA correlate among NQO1 609CC-genotypes but not among 609CT-genotypes Homo sapiens
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.6.5.2 0.0000199
-
 in total leucocytes Homo sapiens
1.6.5.2 0.0000239
-
 in lymphocytes Homo sapiens
1.6.5.2 0.000072
-
 in rectal biopsies of the C609T genotype Homo sapiens
1.6.5.2 0.00011
-
 in rectal biopsies of the C609C genotype Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.6.5.2 NAD(P)H + H+ + oxidized 2,6-dichlorophenolindophenol
-
 Homo sapiens NAD(P)+ + reduced 2,6-dichlorophenolindophenol
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.6.5.2 NAD(P)H:quinone oxidoreductase
-
 Homo sapiens
1.6.5.2 NADPH:quinone oxidoreductase 1
-
 Homo sapiens
1.6.5.2 NQO1
-
 Homo sapiens