Literature summary extracted from

Shi, Q.; Karuppagounder, S.S.; Xu, H.; Pechman, D.; Chen, H.; Gibson, G.E.
Responses of the mitochondrial alpha-ketoglutarate dehydrogenase complex to thiamine deficiency may contribute to regional selective vulnerability (2007), Neurochem. Int., 50, 921-931.

Localization

EC Number	Localization	Comment	Organism	GeneOntology No.	Textmining
1.2.4.2	mitochondrion	-	Mus musculus	5739	-

Organism

EC Number	Organism	UniProt	Comment	Textmining
1.2.4.2	Mus musculus	-	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
1.2.4.2	brain cortex	-	Mus musculus	-
1.2.4.2	thalamic nucleus	submedial thalamic nucleus	Mus musculus	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
1.2.4.2	2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine	-	Mus musculus	[dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2	-	?

Synonyms

EC Number	Synonyms	Comment	Organism
1.2.4.2	E1k	part of the alpha-ketoglutarate dehydrogenase complex	Mus musculus

Cofactor

EC Number	Cofactor	Comment	Organism	Structure
1.2.4.2	thiamine diphosphate	thiamine deficiency reduces the activity of the alpha-ketoglutarate dehydrogenase complex	Mus musculus

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Release 2023.1 (January 2023)