Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Chinnici, C.M.; Yao, Y.; Pratico, D.
    The 5-lipoxygenase enzymatic pathway in the mouse brain: Young versus old (2007), Neurobiol. Aging, 28, 1457-1462.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.13.11.34 (6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyeicosa-6,8,11,14-tetraenoate Mus musculus
-
 leukotriene A4 + H2O is unstable and metabolized to leukotriene B4 ?
1.13.11.34 (6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyeicosa-6,8,11,14-tetraenoate Mus musculus C57BL/6
-
 leukotriene A4 + H2O is unstable and metabolized to leukotriene B4 ?
1.13.11.34 arachidonic acid + O2 Mus musculus
-
 (6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyeicosa-6,8,11,14-tetraenoate
-
 ?
1.13.11.34 arachidonic acid + O2 Mus musculus C57BL/6
-
 (6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyeicosa-6,8,11,14-tetraenoate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.13.11.34 Mus musculus P48999 C57BL/6 mice
-
1.13.11.34 Mus musculus C57BL/6 P48999 C57BL/6 mice
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.13.11.34 brain of young and old mice, comparison of enzyme expression and activity in brain regions, e.g. cortex, hippocampus and cerebellum, overview Mus musculus
-
1.13.11.34 cerebellum highest expresion of the enzyme in brain Mus musculus
-
1.13.11.34 cerebral cortex
-
 Mus musculus
-
1.13.11.34 hippocampus increased enzyme content in older rats, overview Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.13.11.34 (6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyeicosa-6,8,11,14-tetraenoate
-
 Mus musculus leukotriene A4 + H2O
-
 ?
1.13.11.34 (6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyeicosa-6,8,11,14-tetraenoate
-
 Mus musculus leukotriene A4 + H2O is unstable and metabolized to leukotriene B4 ?
1.13.11.34 (6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyeicosa-6,8,11,14-tetraenoate
-
 Mus musculus C57BL/6 leukotriene A4 + H2O
-
 ?
1.13.11.34 (6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyeicosa-6,8,11,14-tetraenoate
-
 Mus musculus C57BL/6 leukotriene A4 + H2O is unstable and metabolized to leukotriene B4 ?
1.13.11.34 arachidonic acid + O2
-
 Mus musculus (6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyeicosa-6,8,11,14-tetraenoate
-
 ?
1.13.11.34 arachidonic acid + O2
-
 Mus musculus C57BL/6 (6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyeicosa-6,8,11,14-tetraenoate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.13.11.34 5-lipoxygenase
-
 Mus musculus
1.13.11.34 5-LO
-
 Mus musculus