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Literature summary extracted from

  • Lee, Y.K.; Schmidt, D.R.; Cummins, C.L.; Choi, M.; Peng, L.; Zhang, Y.; Goodwin, B.; Hammer, R.E.; Mangelsdorf, D.J.; Kliewer, S.A.
    Liver receptor homolog-1 regulates bile acid homeostasis but is not essential for feedback regulation of bile acid synthesis (2008), Mol. Endocrinol., 22, 1345-1356.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.14.139 additional information enzyme expression is repressed by the nuclear bile acid receptor FXR Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.14.139 5beta-cholestan-3alpha,7alpha-diol + [reduced NADPH-hemoprotein reductase] + O2 Mus musculus a key step in bile acid synthesis 5beta-cholestan-3alpha,7alpha,12alpha-triol + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
1.14.14.139 additional information Mus musculus while Cyp8b1 repression by the nuclear bile acid receptor FXR is also intact in mice deficient for liver receptor homolog 1, LRH-1, in hepatocytes, basal CYP8B1 mRNA levels are significantly decreased and there are corresponding changes in the composition of the bile acid pool. Liver receptor homolog 1, LRH-1, is either not involved in the feedback regulation of bile acid synthesis or is compensated for by other factors ?
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 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.14.139 Mus musculus
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-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.14.139 5beta-cholestan-3alpha,7alpha-diol + [reduced NADPH-hemoprotein reductase] + O2
-
 Mus musculus 5beta-cholestan-3alpha,7alpha,12alpha-triol + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
1.14.14.139 5beta-cholestan-3alpha,7alpha-diol + [reduced NADPH-hemoprotein reductase] + O2 a key step in bile acid synthesis Mus musculus 5beta-cholestan-3alpha,7alpha,12alpha-triol + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
1.14.14.139 additional information while Cyp8b1 repression by the nuclear bile acid receptor FXR is also intact in mice deficient for liver receptor homolog 1, LRH-1, in hepatocytes, basal CYP8B1 mRNA levels are significantly decreased and there are corresponding changes in the composition of the bile acid pool. Liver receptor homolog 1, LRH-1, is either not involved in the feedback regulation of bile acid synthesis or is compensated for by other factors Mus musculus ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.14.139 CYP8B1
-
 Mus musculus
1.14.14.139 sterol 12alpha-hydroxylase
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 Mus musculus

Expression

EC Number Organism Comment Expression
1.14.14.139 Mus musculus in mice deficient for liver receptor homolog LRH-1, basal CYP8B1 mRNA levels are significantly decreased. CYP8B1 repression by farnesoid X receptor FXR is intact in mice deficient for LRH-1 in hepatocytes down