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Literature summary extracted from

  • Peter, J.; Alenina, N.; Bader, M.; Walther, D.J.
    Development of antithrombotic miniribozymes that target peripheral tryptophan hydroxylase (2007), Mol. Cell. Biochem., 295, 205-215.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.14.16.4 DTT
-
 Mus musculus
1.14.16.4 Fe(NH4)2(SO4)2
-
 Mus musculus

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.14.16.4 secondary structure of TPH1 RNA, overview Mus musculus

Protein Variants

EC Number Protein Variants Comment Organism
1.14.16.4 additional information mice deficient in TPH1 and serotonin exhibit a reduced risk of thrombosis and thromboembolism, development of antithrombotic hammerhead miniribozymes with site-specific cleavage activity against short synthetic Tph1 RNA substrates targeting peripheral tryptophan hydroxylase, method development and evaluation, overview Mus musculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.16.4 additional information development of antithrombotic miniribozymes that target peripheral tryptophan hydroxylase, overview Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.16.4 L-tryptophan + tetrahydrobiopterin + O2 Mus musculus rate-limiting enzyme in serotonin biosynthesis, mice deficient in peripheral tryptophan hydroxylase and serotonin exhibit a reduced risk of thrombosis and thromboembolism 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.16.4 Mus musculus
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.16.4 L-tryptophan + 6-methyl-tetrahydrobiopterin + O2
-
 Mus musculus 5-hydroxy-L-tryptophan + 6-methyl-4a-hydroxytetrahydrobiopterin
-
 ?
1.14.16.4 L-tryptophan + tetrahydrobiopterin + O2
-
 Mus musculus 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin
-
 ?
1.14.16.4 L-tryptophan + tetrahydrobiopterin + O2 rate-limiting enzyme in serotonin biosynthesis, mice deficient in peripheral tryptophan hydroxylase and serotonin exhibit a reduced risk of thrombosis and thromboembolism Mus musculus 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.16.4 peripheral tryptophan hydroxylase
-
 Mus musculus
1.14.16.4 TPH
-
 Mus musculus
1.14.16.4 TPH1
-
 Mus musculus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.14.16.4 30
-
 assay at Mus musculus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.14.16.4 7.5
-
 assay at Mus musculus