EC Number | Application | Comment | Organism |
---|---|---|---|
1.1.1.141 | medicine | expression in nontumorigenic IEC-18 cells, with and without K-RasV12 and analysis of the ability of cells to form tumors in nu/nu mice. Transformed cells show increased 15-hydroxyprostaglandin dehydrogenase activity with decreased prostaglandin E2 and prostaglandin I2 levels, cyclooxygenase-2 and microsomal prostaglandin E synthase-1 expression and proliferation rates. Xenografts of cells expressing both the enzyme and K-RasV12 exhibit delayed tumor formation with negligible cyclooxygenase-2 and microsomal prostaglandin E synthase-1 expression and significantly decreased prostaglandin E2 levels. Tumors have decreased staining of the proliferative marker, Ki-67, and a significant increase in apoptosis in the central region of the tumor | Rattus norvegicus |
1.1.1.141 | medicine | PGDH expression suppresses K-RasV12-mediated tumorigenesis in intestinal epithelial cells | Rattus norvegicus |
EC Number | Cloned (Comment) | Organism |
---|---|---|
1.1.1.141 | expression in IEC-18 cell | Rattus norvegicus |
EC Number | Protein Variants | Comment | Organism |
---|---|---|---|
1.1.1.141 | additional information | expression in nontumorigenic IEC-18 cells, with and without K-RasV12 and analysis of the ability of cells to form tumors in nu/nu mice. Transformed cells show increased 15-hydroxyprostaglandin dehydrogenase activity with decreased prostaglandin E2 and prostaglandin I2 levels, cyclooxygenase-2 and microsomal prostaglandin E synthase-1 expression and proliferation rates. Xenografts of cells expressing both the enzyme and K-RasV12 exhibit delayed tumor formation with negligible cyclooxygenase-2 and microsomal prostaglandin E synthase-1 expression and significantly decreased prostaglandin E2 levels. Tumors have decreased staining of the proliferative marker, Ki-67, and a significant increase in apoptosis in the central region of the tumor | Rattus norvegicus |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
1.1.1.141 | 5-[[4-(ethoxycarbonyl)phenyl]azo]2-hydroxy-benzene acetic acid | CAY-10397 | Rattus norvegicus |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.1.1.141 | Rattus norvegicus | - |
- |
- |
1.1.1.141 | Rattus norvegicus | O08699 | - |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
1.1.1.141 | IEC-18 cell | - |
Rattus norvegicus | - |
1.1.1.141 | intestinal epithelium | - |
Rattus norvegicus | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.1.1.141 | prostaglandin E2 + NAD+ | - |
Rattus norvegicus | 15-ketoprostaglandin E2 + NADH + H+ | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
1.1.1.141 | 15-PGDH | - |
Rattus norvegicus |
1.1.1.141 | NAD+-dependent 15-hydroxyprostaglandin dehydrogenase | - |
Rattus norvegicus |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
1.1.1.141 | NAD+ | dependent on | Rattus norvegicus |