EC Number | Cloned (Comment) | Organism |
---|---|---|
3.5.4.1 | expression of the enzyme in Rattus norvegicus, BDIX rats, in induced colorectal adenocarcinoma in a gene therapy approach | Escherichia coli |
EC Number | Protein Variants | Comment | Organism |
---|---|---|---|
3.5.4.1 | additional information | expression of the enzyme in Rattus norvegicus, BDIX rats, in induced colorectal adenocarcinoma in a gene therapy approach leads to intratumor chemotherapy using 5-fluorocytosine, which is locally converted to 5-fluorouracil, the treatment results in destruction of the gene-modified tumor, other physiological processes might contribute to the tumor destruction, overview | Escherichia coli |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.5.4.1 | cytosine + H2O | Escherichia coli | treatment of BDIX rat colon cancer cells using the cytosine deaminase/5-fluorocytosine suicide system induces apoptosis, modulation of the proteome, and Hsp90beta phosphorylation, mechanism of the anticancer effect, overview | uracil + NH3 | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.5.4.1 | Escherichia coli | - |
- |
- |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.5.4.1 | 5-fluorocytosine + H2O | - |
Escherichia coli | 5-fluorouracil + NH3 | - |
? | |
3.5.4.1 | cytosine + H2O | - |
Escherichia coli | uracil + NH3 | - |
? | |
3.5.4.1 | cytosine + H2O | treatment of BDIX rat colon cancer cells using the cytosine deaminase/5-fluorocytosine suicide system induces apoptosis, modulation of the proteome, and Hsp90beta phosphorylation, mechanism of the anticancer effect, overview | Escherichia coli | uracil + NH3 | - |
? |