Literature summary extracted from

Dhagat, U.; Carbone, V.; Chung, R.P.; Matsunaga, T.; Endo, S.; Hara, A.; El-Kabbani, O.
A salicylic acid-based analogue discovered from virtual screening as a potent inhibitor of human 20alpha-hydroxysteroid dehydrogenase (2007), Med. Chem., 3, 546-550.

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
1.1.1.149	3,5-diiodosalicylic acid	competitive	Homo sapiens
1.1.1.149	Acetylsalicylate	-	Homo sapiens
1.1.1.149	salicylate	-	Homo sapiens

Organism

EC Number	Organism	UniProt	Comment	Textmining
1.1.1.149	Homo sapiens	-	isoform AKR1C1	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
1.1.1.149	5beta-pregnane-3alpha,20alpha-diol + NAD(P)+	-	Homo sapiens	5beta-pregnan-20alpha-ol-3-one + NAD(P)H + H+	-	?

Ki Value [mM]

EC Number	Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
1.1.1.149	0.000009	-	3,5-diiodosalicylic acid	-	Homo sapiens
1.1.1.149	0.0078	-	salicylate	-	Homo sapiens
1.1.1.149	0.021	-	Acetylsalicylate	-	Homo sapiens

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Release 2023.1 (January 2023)