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Literature summary extracted from

  • Amory, J.K.; Anawalt, B.D.; Matsumoto, A.M.; Page, S.T.; Bremner, W.J.; Wang, C.; Swerdloff, R.S.; Clark, R.V.
    The effect of 5alpha-reductase inhibition with dutasteride and finasteride on bone mineral density, serum lipoproteins, hemoglobin, prostate specific antigen and sexual function in healthy young men (2008), J. Urol., 179, 2333-2338.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.3.1.22 dutasteride 0.5 mg/day, inhibitor of type 1 and type 2 5alpha reductase; treatment with 0.5 mg daily for 1 year leads to reduced enzyme activity Homo sapiens
1.3.1.22 finasteride 5.0 mg/day, inhibits type 2 5alpha-reductase; treatment with 5 mg daily for 1 year leads to reduced enzyme activity Homo sapiens
1.3.99.5 dutasteride inhibits type 1 5alpha-reductase Homo sapiens
1.3.99.5 finasteride inhibits type 2 5alpha-reductase Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.3.99.5 testosterone + reduced acceptor Homo sapiens
-
 5alpha-dihydrotestosterone + acceptor
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.3.1.22 Homo sapiens
-
-
-
1.3.99.5 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.3.1.22 testosterone + NADPH + H+
-
 Homo sapiens 5alpha-dihydrotestosterone + NADP+
-
 ?
1.3.99.5 testosterone + reduced acceptor
-
 Homo sapiens 5alpha-dihydrotestosterone + acceptor
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.3.1.22 type 1 5alpha-reductase
-
 Homo sapiens
1.3.1.22 type 2 5alpha-reductase
-
 Homo sapiens
1.3.99.5 type 1 5alpha-reductase
-
 Homo sapiens
1.3.99.5 type 2 5alpha-reductase
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.3.1.22 NADPH
-
 Homo sapiens