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Literature summary extracted from

  • Fajmut, A.; Brumen, M.
    MLC-kinase/phosphatase control of Ca2+ signal transduction in airway smooth muscles (2008), J. Theor. Biol., 252, 474-481.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.11.18 Calmodulin required Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.7.11.18 additional information
-
 additional information Michaelis-Menten kinetics, kinetic scheme of the mathematical model considers interactions among Ca2+, calmodulin and MLCK, and the well-known 4-state actomyosin latch bridge model, whereby a link between them is accomplished by the conservation relation of all species of MLCK, detailed overview Rattus norvegicus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.11.18 Ca2+ required Rattus norvegicus
2.7.11.18 Mg2+
-
 Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.18 ATP + myosin light chain Rattus norvegicus in airway smooth muscles, kinase/phosphatase-dependent phosphorylation and dephosphorylation of the myosin light chain is an important step in calcium signalling pathway from the variation of Ca2+ concentration in cytosol to the force development ADP + myosin light chain phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.18 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.18 lung
-
 Rattus norvegicus
-
2.7.11.18 smooth muscle airway Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.18 ATP + myosin light chain
-
 Rattus norvegicus ADP + myosin light chain phosphate
-
 ?
2.7.11.18 ATP + myosin light chain in airway smooth muscles, kinase/phosphatase-dependent phosphorylation and dephosphorylation of the myosin light chain is an important step in calcium signalling pathway from the variation of Ca2+ concentration in cytosol to the force development Rattus norvegicus ADP + myosin light chain phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.11.18 MLC-kinase
-
 Rattus norvegicus
2.7.11.18 MLCK
-
 Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.11.18 ATP
-
 Rattus norvegicus