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Literature summary extracted from

  • ORourke, A.M.; Wang, E.Y.; Miller, A.; Podar, E.M.; Scheyhing, K.; Huang, L.; Kessler, C.; Gao, H.; Ton-Nu, H.T.; Macdonald, M.T.; Jones, D.S.; Linnik, M.D.
    Anti-inflammatory effects of LJP 1586 [Z-3-fluoro-2-(4-methoxybenzyl)allylamine hydrochloride], an amine-based inhibitor of semicarbazide-sensitive amine oxidase activity (2008), J. Pharmacol. Exp. Ther., 324, 867-875.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.4.3.4 (Z)-3-fluoro-2-(4-methoxybenzyl)allylamine hydrochloride i.e. LJP 1586. Potent, specific, and orally available inhibitor of SSAO activity is an effective anti-inflammatory compound in vivo; i.e. LJP 1586. Potent, specific, and orally available inhibitor of SSAO activity is an effective anti-inflammatory compound in vivo Homo sapiens
1.4.3.21 (Z)-3-fluoro-2-(4-methoxybenzyl)allylamine hydrochloride i.e. LJP 1586. Potent, specific, and orally available inhibitor of SSAO activity is an effective anti-inflammatory compound in vivo Homo sapiens
1.4.3.21 (Z)-3-fluoro-2-(4-methoxybenzyl)allylamine hydrochloride i.e. LJP 1586. Potent, specific, and orally available inhibitor of SSAO activity is an effective anti-inflammatory compound in vivo Mus musculus
1.4.3.21 (Z)-3-fluoro-2-(4-methoxybenzyl)allylamine hydrochloride i.e. LJP 1586. Potent, specific, and orally available inhibitor of SSAO activity is an effective anti-inflammatory compound in vivo Rattus norvegicus
1.4.3.22 (Z)-3-fluoro-2-(4-methoxybenzyl)allylamine hydrochloride i.e. LJP 1586. Potent, specific, and orally available inhibitor of SSAO activity is an effective anti-inflammatory compound in vivo Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
1.4.3.4 Homo sapiens P21397 recombinant
-
1.4.3.4 Homo sapiens P27338 recombinant
-
1.4.3.21 Homo sapiens
-
-
-
1.4.3.21 Mus musculus
-
-
-
1.4.3.21 Rattus norvegicus
-
-
-
1.4.3.22 Homo sapiens
-
 recombinant
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.4.3.21 aorta
-
 Mus musculus
-
1.4.3.21 lung
-
 Rattus norvegicus
-
1.4.3.21 umbilical cord
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.4.3.4 benzylamine + H2O + O2
-
 Homo sapiens benzaldehyde + NH3 + H2O2
-
 ?
1.4.3.21 benzylamine + H2O + O2
-
 Mus musculus benzaldehyde + NH3 + H2O2
-
 ?
1.4.3.21 benzylamine + H2O + O2
-
 Homo sapiens benzaldehyde + NH3 + H2O2
-
 ?
1.4.3.21 benzylamine + H2O + O2
-
 Rattus norvegicus benzaldehyde + NH3 + H2O2
-
 ?
1.4.3.22 benzylamine + H2O + O2
-
 Homo sapiens benzaldehyde + NH3 + H2O2
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.4.3.4 MAO-A
-
 Homo sapiens
1.4.3.4 MAO-B
-
 Homo sapiens
1.4.3.21 SSAO
-
 Mus musculus
1.4.3.21 SSAO
-
 Homo sapiens
1.4.3.21 SSAO
-
 Rattus norvegicus
1.4.3.22 DAO
-
 Homo sapiens

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.4.3.4 0.0022
-
-
 Homo sapiens (Z)-3-fluoro-2-(4-methoxybenzyl)allylamine hydrochloride
1.4.3.4 0.098
-
-
 Homo sapiens (Z)-3-fluoro-2-(4-methoxybenzyl)allylamine hydrochloride
1.4.3.21 0.000004
-
-
 Mus musculus (Z)-3-fluoro-2-(4-methoxybenzyl)allylamine hydrochloride
1.4.3.21 0.000009
-
-
 Rattus norvegicus (Z)-3-fluoro-2-(4-methoxybenzyl)allylamine hydrochloride
1.4.3.21 0.000027
-
 enzyme from umbilical cord Homo sapiens (Z)-3-fluoro-2-(4-methoxybenzyl)allylamine hydrochloride
1.4.3.21 0.000043
-
 lysates of human SSAO-expressing CHO cells Homo sapiens (Z)-3-fluoro-2-(4-methoxybenzyl)allylamine hydrochloride
1.4.3.22 0.096
-
-
 Homo sapiens (Z)-3-fluoro-2-(4-methoxybenzyl)allylamine hydrochloride