EC Number | Crystallization (Comment) | Organism |
---|---|---|
2.5.1.78 | molecular modeling of enzyme with inhibitor 5-nitro-6-[[(2R,3R,4R)-2,3,4,5 tetrahydroxypentyl]sulfanyl]pyrimidine-2,4(1H,3H)-dione | Bacillus subtilis |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
2.5.1.9 | 2,4-dioxo-6-[[(2R,3R,4R)-2,3,4,5-tetrahydroxypentyl]sulfanyl]-1,2,3,4-tetrahydropyrimidin-5-aminium chloride | - |
Escherichia coli | |
2.5.1.9 | 2,4-dioxo-6-[[(2R,3R,4R)-2,3,4,5-tetrahydroxypentyl]sulfanyl]-1,2,3,4-tetrahydropyrimidin-5-aminium chloride | - |
Mycobacterium tuberculosis | |
2.5.1.9 | 5-nitro-6-[[(2R,3R,4R)-2,3,4,5 tetrahydroxypentyl]sulfanyl]pyrimidine-2,4(1H,3H)-dione | - |
Escherichia coli | |
2.5.1.9 | 5-nitro-6-[[(2R,3R,4R)-2,3,4,5 tetrahydroxypentyl]sulfanyl]pyrimidine-2,4(1H,3H)-dione | - |
Mycobacterium tuberculosis | |
2.5.1.78 | 2,4-dioxo-6-[[(2R,3R,4R)-2,3,4,5-tetrahydroxypentyl]sulfanyl]-1,2,3,4-tetrahydropyrimidin-5-aminium chloride | inhibition of both lumazine synthase and riboflavin synthase | Bacillus subtilis | |
2.5.1.78 | 2,4-dioxo-6-[[(2R,3R,4R)-2,3,4,5-tetrahydroxypentyl]sulfanyl]-1,2,3,4-tetrahydropyrimidin-5-aminium chloride | inhibition of both lumazine synthase and riboflavin synthase | Mycobacterium tuberculosis | |
2.5.1.78 | 2,4-dioxo-6-[[(2R,3R,4R)-2,3,4,5-tetrahydroxypentyl]sulfanyl]-1,2,3,4-tetrahydropyrimidin-5-aminium chloride | inhibition of both lumazine synthase and riboflavin synthase | Schizosaccharomyces pombe | |
2.5.1.78 | 5-nitro-6-[[(2R,3R,4R)-2,3,4,5 tetrahydroxypentyl]sulfanyl]pyrimidine-2,4(1H,3H)-dione | inhibition of both lumazine synthase and riboflavin synthase | Bacillus subtilis | |
2.5.1.78 | 5-nitro-6-[[(2R,3R,4R)-2,3,4,5 tetrahydroxypentyl]sulfanyl]pyrimidine-2,4(1H,3H)-dione | inhibition of both lumazine synthase and riboflavin synthase | Mycobacterium tuberculosis | |
2.5.1.78 | 5-nitro-6-[[(2R,3R,4R)-2,3,4,5 tetrahydroxypentyl]sulfanyl]pyrimidine-2,4(1H,3H)-dione | inhibition of both lumazine synthase and riboflavin synthase | Schizosaccharomyces pombe |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.5.1.9 | Escherichia coli | - |
- |
- |
2.5.1.9 | Mycobacterium tuberculosis | - |
- |
- |
2.5.1.78 | Bacillus subtilis | - |
- |
- |
2.5.1.78 | Mycobacterium tuberculosis | - |
- |
- |
2.5.1.78 | Schizosaccharomyces pombe | - |
- |
- |
EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|---|
2.5.1.78 | 27 | - |
assay at | Bacillus subtilis |
2.5.1.78 | 27 | - |
assay at | Schizosaccharomyces pombe |
2.5.1.78 | 37 | - |
assay at | Mycobacterium tuberculosis |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
2.5.1.78 | 7 | - |
assay at | Bacillus subtilis |
2.5.1.78 | 7 | - |
assay at | Schizosaccharomyces pombe |
2.5.1.78 | 7 | - |
assay at | Mycobacterium tuberculosis |
EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|---|
2.5.1.9 | 0.00056 | - |
5-nitro-6-[[(2R,3R,4R)-2,3,4,5 tetrahydroxypentyl]sulfanyl]pyrimidine-2,4(1H,3H)-dione | pH 7.0, 27°C | Mycobacterium tuberculosis | |
2.5.1.9 | 0.0025 | - |
2,4-dioxo-6-[[(2R,3R,4R)-2,3,4,5-tetrahydroxypentyl]sulfanyl]-1,2,3,4-tetrahydropyrimidin-5-aminium chloride | pH 7.0, 27°C | Mycobacterium tuberculosis | |
2.5.1.9 | 0.0027 | - |
5-nitro-6-[[(2R,3R,4R)-2,3,4,5 tetrahydroxypentyl]sulfanyl]pyrimidine-2,4(1H,3H)-dione | pH 7.0, 27°C | Escherichia coli | |
2.5.1.9 | 0.047 | - |
2,4-dioxo-6-[[(2R,3R,4R)-2,3,4,5-tetrahydroxypentyl]sulfanyl]-1,2,3,4-tetrahydropyrimidin-5-aminium chloride | pH 7.0, 27°C | Escherichia coli | |
2.5.1.78 | 0.00016 | - |
2,4-dioxo-6-[[(2R,3R,4R)-2,3,4,5-tetrahydroxypentyl]sulfanyl]-1,2,3,4-tetrahydropyrimidin-5-aminium chloride | pH 7.0, 27°C | Schizosaccharomyces pombe | |
2.5.1.78 | 0.002 | - |
5-nitro-6-[[(2R,3R,4R)-2,3,4,5 tetrahydroxypentyl]sulfanyl]pyrimidine-2,4(1H,3H)-dione | pH 7.0, 27°C | Schizosaccharomyces pombe | |
2.5.1.78 | 0.0026 | - |
2,4-dioxo-6-[[(2R,3R,4R)-2,3,4,5-tetrahydroxypentyl]sulfanyl]-1,2,3,4-tetrahydropyrimidin-5-aminium chloride | pH 7.0, 27°C | Bacillus subtilis | |
2.5.1.78 | 0.011 | - |
5-nitro-6-[[(2R,3R,4R)-2,3,4,5 tetrahydroxypentyl]sulfanyl]pyrimidine-2,4(1H,3H)-dione | pH 7.0, 27°C | Mycobacterium tuberculosis | |
2.5.1.78 | 0.026 | - |
5-nitro-6-[[(2R,3R,4R)-2,3,4,5 tetrahydroxypentyl]sulfanyl]pyrimidine-2,4(1H,3H)-dione | pH 7.0, 27°C | Bacillus subtilis | |
2.5.1.78 | 0.031 | - |
2,4-dioxo-6-[[(2R,3R,4R)-2,3,4,5-tetrahydroxypentyl]sulfanyl]-1,2,3,4-tetrahydropyrimidin-5-aminium chloride | pH 7.0, 27°C | Mycobacterium tuberculosis |