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Literature summary extracted from

  • Cartagena, C.M.; Ahmed, F.; Burns, M.P.; Pajoohesh-Ganji, A.; Pak, D.T.; Faden, A.I.; Rebeck, G.W.
    Cortical injury increases cholesterol 24S hydroxylase (Cyp46) levels in the rat brain (2008), J. Neurotrauma, 25, 1087-1098.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.14.14.25 additional information cortical injury increases cholesterol 24S hydroxylase levels in the rat brain, overview Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.14.25 cholesterol + [reduced NADPH-hemoprotein reductase] + H+ + O2 Rattus norvegicus 24-hydroxycholesterol induces, through the liver X receptor, activation of genes involved in cholesterol efflux, including the ATP-binding cassette transporter A1 and apolipoprotein E, overview (24S)-24-hydroxycholesterol + [oxidized NADPH-hemoprotein reductase] + H2O
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 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.14.25 Rattus norvegicus
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 Sprague-Dawley rats
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Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.14.25 brain enzyme levels in healthy and injured brain, primary rat microglia, overview Rattus norvegicus
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1.14.14.25 hippocampus
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 Rattus norvegicus
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1.14.14.25 neuron primary hippocampal neurons Rattus norvegicus
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.14.25 cholesterol + [reduced NADPH-hemoprotein reductase] + H+ + O2
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 Rattus norvegicus (24S)-24-hydroxycholesterol + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
1.14.14.25 cholesterol + [reduced NADPH-hemoprotein reductase] + H+ + O2 24-hydroxycholesterol induces, through the liver X receptor, activation of genes involved in cholesterol efflux, including the ATP-binding cassette transporter A1 and apolipoprotein E, overview Rattus norvegicus (24S)-24-hydroxycholesterol + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.14.25 cholesterol 24S hydroxylase
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 Rattus norvegicus
1.14.14.25 CYP46
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 Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.14.25 NADPH
-
 Rattus norvegicus