Literature summary extracted from

Park, K.W.; Jin, B.K.
Thrombin-induced oxidative stress contributes to the death of hippocampal neurons: role of neuronal NADPH oxidase (2008), J. Neurosci. Res., 86, 1053-1063.

Activating Compound

EC Number	Activating Compound	Comment	Organism	Structure
1.6.3.1	thrombin	after addition to cell culture, expression of NADPH oxidase subunits p47phox and p67phox occurs, accompanied by up-regulation in the expression of cytosolic enzyme components Rac 1 and p67phox, and the translocation of cytosolic subunits p47phox and p67phox to the membrane. Thrombin-induced reactive oxygen species production, protein oxidation, and loss of cultured hippocampal neurons are partially attenuated by NADPH oxidase inhibition and/or by several antioxidants	Rattus norvegicus

Application

EC Number	Application	Comment	Organism
1.6.3.1	medicine	after addition of thrombin to cell culture, expression of NADPH oxidase subunits p47phox and p67phox occurs, accompanied by up-regulation in the expression of cytosolic enzyme components Rac 1 and p67phox, and the translocation of cytosolic subunits p47phox and p67phox to the membrane. Thrombin-induced reactive oxygen species production, protein oxidation, and loss of cultured hippocampal neurons are partially attenuated by NADPH oxidase inhibition and/or by several antioxidants	Rattus norvegicus

Organism

EC Number	Organism	UniProt	Comment	Textmining
1.6.3.1	Rattus norvegicus	-	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
1.6.3.1	hippocampus	neuron-enriched hippocampal culture	Rattus norvegicus	-

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Release 2023.1 (January 2023)