Literature summary extracted from
Steuber, H.; Heine, A.; Podjarny, A.; Klebe, G.
Merging the binding sites of aldose and aldehyde reductase for detection of inhibitor selectivity-determining features (2008), J. Mol. Biol., 379, 991-1016.
Protein Variants
EC Number |
Protein Variants |
Comment |
Organism |
---|
1.1.1.21 |
C303D |
introduction of residue from binding pocket of isoform ALR1 into ALR2, analysis of binding properties of inhibitors |
Homo sapiens |
1.1.1.21 |
F121P |
introduction of residue from binding pocket of isoform ALR1 into ALR2, analysis of binding properties of inhibitors |
Homo sapiens |
1.1.1.21 |
L300A |
introduction of residue from binding pocket of isoform ALR1 into ALR2, analysis of binding properties of inhibitors |
Homo sapiens |
1.1.1.21 |
L301M |
introduction of residue from binding pocket of isoform ALR1 into ALR2, analysis of binding properties of inhibitors |
Homo sapiens |
1.1.1.21 |
S302R |
introduction of residue from binding pocket of isoform ALR1 into ALR2, analysis of binding properties of inhibitors |
Homo sapiens |
1.1.1.21 |
V47I |
introduction of residue from binding pocket of isoform ALR1 into ALR2, analysis of binding properties of inhibitors |
Homo sapiens |
Inhibitors
EC Number |
Inhibitors |
Comment |
Organism |
Structure |
---|
1.1.1.21 |
(2-[(4-bromo-2-fluorobenzyl)carbamoyl]-5-chlorophenoxy)acetic acid |
thermodynamic binding data for isoform ALR2 and mutants |
Homo sapiens |
|
1.1.1.21 |
(3-[(5-chloro-1,3-benzothiazol-2-yl)methyl]-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)acetic acid |
thermodynamic binding data for isoform ALR2 and mutants |
Homo sapiens |
|
1.1.1.21 |
(5-chloro-2-[(3-nitrobenzyl)carbamoyl]phenoxy)acetic acid |
thermodynamic binding data for isoform ALR2 and mutants |
Homo sapiens |
|
1.1.1.21 |
fidarestat |
thermodynamic binding data for isoform ALR2 and mutants |
Homo sapiens |
|
1.1.1.21 |
sorbinil |
thermodynamic binding data for isoform ALR2 and mutants |
Homo sapiens |
|
1.1.1.21 |
Tolrestat |
thermodynamic binding data for isoform ALR2 and mutants |
Homo sapiens |
|
1.1.1.21 |
zopolrestat |
thermodynamic binding data for isoform ALR2 and mutants |
Homo sapiens |
|
Organism
EC Number |
Organism |
UniProt |
Comment |
Textmining |
---|
1.1.1.21 |
Homo sapiens |
P15121 |
isoform ALR2 |
- |