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Literature summary extracted from

  • Steuber, H.; Heine, A.; Podjarny, A.; Klebe, G.
    Merging the binding sites of aldose and aldehyde reductase for detection of inhibitor selectivity-determining features (2008), J. Mol. Biol., 379, 991-1016.
    View publication on PubMed

Protein Variants

EC Number Protein Variants Comment Organism
1.1.1.21 C303D introduction of residue from binding pocket of isoform ALR1 into ALR2, analysis of binding properties of inhibitors Homo sapiens
1.1.1.21 F121P introduction of residue from binding pocket of isoform ALR1 into ALR2, analysis of binding properties of inhibitors Homo sapiens
1.1.1.21 L300A introduction of residue from binding pocket of isoform ALR1 into ALR2, analysis of binding properties of inhibitors Homo sapiens
1.1.1.21 L301M introduction of residue from binding pocket of isoform ALR1 into ALR2, analysis of binding properties of inhibitors Homo sapiens
1.1.1.21 S302R introduction of residue from binding pocket of isoform ALR1 into ALR2, analysis of binding properties of inhibitors Homo sapiens
1.1.1.21 V47I introduction of residue from binding pocket of isoform ALR1 into ALR2, analysis of binding properties of inhibitors Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.21 (2-[(4-bromo-2-fluorobenzyl)carbamoyl]-5-chlorophenoxy)acetic acid thermodynamic binding data for isoform ALR2 and mutants Homo sapiens
1.1.1.21 (3-[(5-chloro-1,3-benzothiazol-2-yl)methyl]-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)acetic acid thermodynamic binding data for isoform ALR2 and mutants Homo sapiens
1.1.1.21 (5-chloro-2-[(3-nitrobenzyl)carbamoyl]phenoxy)acetic acid thermodynamic binding data for isoform ALR2 and mutants Homo sapiens
1.1.1.21 fidarestat thermodynamic binding data for isoform ALR2 and mutants Homo sapiens
1.1.1.21 sorbinil thermodynamic binding data for isoform ALR2 and mutants Homo sapiens
1.1.1.21 Tolrestat thermodynamic binding data for isoform ALR2 and mutants Homo sapiens
1.1.1.21 zopolrestat thermodynamic binding data for isoform ALR2 and mutants Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.21 Homo sapiens P15121 isoform ALR2
-