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Literature summary extracted from

  • Burk, D.L.; Hwang, J.; Kwok, E.; Marrone, L.; Goodfellow, V.; Dmitrienko, G.I.; Berghuis, A.M.
    Structural studies of the final enzyme in the alpha-aminoadipate pathway-saccharopine dehydrogenase from Saccharomyces cerevisiae (2007), J. Mol. Biol., 373, 745-754.
    View publication on PubMed

Application

EC Number Application Comment Organism
1.5.1.7 medicine target for antimicrobial drug development Saccharomyces cerevisiae

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.5.1.7 expressed in Escherichia coli B834(DE3) cells Saccharomyces cerevisiae

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
1.5.1.7 in complex with NAD+ and saccharopine, hanging drop vapour diffusion method in 20% (w/v) PEG 8000, 0.1 M MES (pH 6.0), and 0.2 M Ca(OAc)2 Saccharomyces cerevisiae

Organism

EC Number Organism UniProt Comment Textmining
1.5.1.7 Saccharomyces cerevisiae P38998
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.5.1.7 glutathione Sepharose column chromatography Saccharomyces cerevisiae

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.5.1.7 N6-(L-1,3-dicarboxypropyl)-L-lysine + NAD+ + H2O
-
 Saccharomyces cerevisiae L-lysine + 2-oxoglutarate + NADH + H+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.5.1.7 SDH
-
 Saccharomyces cerevisiae

Cofactor

EC Number Cofactor Comment Organism Structure
1.5.1.7 NAD+
-
 Saccharomyces cerevisiae