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Literature summary extracted from

  • Wen, X.; Sun, H.; Liu, J.; Cheng, K.; Zhang, P.; Zhang, L.; Hao, J.; Zhang, L.; Ni, P.; Zographos, S.E.; Leonidas, D.D.; Alexacou, K.M.; Gimisis, T.; Hayes, J.M.; Oikonomakos, N.G.
    Naturally occurring pentacyclic triterpenes as inhibitors of glycogen phosphorylase: synthesis, structure-activity relationships, and X-ray crystallographic studies (2008), J. Med. Chem., 51, 3540-3554.
    View publication on PubMed

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
2.4.1.1
-
 Oryctolagus cuniculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.4.1.1 Caffeine
-
 Oryctolagus cuniculus
2.4.1.1 additional information pentacyclic triterpenes may exert hypoglycemic effects, at least in part, through glycogen phosphorylase inhibition Oryctolagus cuniculus

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.1 Oryctolagus cuniculus P00489
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.1.1 muscle
-
 Oryctolagus cuniculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.1.1 glycogen + glucose 1-phosphate
-
 Oryctolagus cuniculus glycogen + phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.4.1.1 glycogen phosphorylase a
-
 Oryctolagus cuniculus
2.4.1.1 GPA
-
 Oryctolagus cuniculus

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
2.4.1.1 0.114
-
 pH 7.2, 22°C Oryctolagus cuniculus Caffeine