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Literature summary extracted from

  • Chimenti, F.; Maccioni, E.; Secci, D.; Bolasco, A.; Chimenti, P.; Granese, A.; Befani, O.; Turini, P.; Alcaro, S.; Ortuso, F.; Cardia, M.C.; Distinto, S.
    Selective inhibitory activity against MAO and molecular modeling studies of 2-thiazolylhydrazone derivatives (2007), J. Med. Chem., 50, 707-712.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.4.3.4 (1Z)-2-methylcyclohexanone (4-phenyl-1,3-thiazol-2-yl)hydrazone pKi: 7.39 Homo sapiens
1.4.3.4 2,4-dichlorobenzaldehyde (4-methyl-1,3-thiazol-2-yl)hydrazone pKi: 7.92 Homo sapiens
1.4.3.4 2,4-dichlorobenzaldehyde (4-phenyl-1,3-thiazol-2-yl)hydrazone pKi: 7.03 Homo sapiens
1.4.3.4 2-methylbenzaldehyde (4-methyl-1,3-thiazol-2-yl)hydrazone pKi: 7.45 Homo sapiens
1.4.3.4 2-methylbenzaldehyde (4-phenyl-1,3-thiazol-2-yl)hydrazone pKi: 7.18 Homo sapiens
1.4.3.4 3,4-dimethoxybenzaldehyde (4-methyl-1,3-thiazol-2-yl)hydrazone pKi: 7.88 Homo sapiens
1.4.3.4 3,4-dimethoxybenzaldehyde (4-phenyl-1,3-thiazol-2-yl)hydrazone pKi: 7.52 Homo sapiens
1.4.3.4 4-chlorobenzaldehyde (4-methyl-1,3-thiazol-2-yl)hydrazone pKi: 7.42 Homo sapiens
1.4.3.4 4-chlorobenzaldehyde (4-phenyl-1,3-thiazol-2-yl)hydrazone pKi: 7.0 Homo sapiens
1.4.3.4 4-methoxybenzaldehyde (4-methyl-1,3-thiazol-2-yl)hydrazone pKi: 7.72 Homo sapiens
1.4.3.4 4-methoxybenzaldehyde (4-phenyl-1,3-thiazol-2-yl)hydrazone pKi: 7.3 Homo sapiens
1.4.3.4 4-methylbenzaldehyde (4-methyl-1,3-thiazol-2-yl)hydrazone pKi: 6.69 Homo sapiens
1.4.3.4 4-methylbenzaldehyde (4-phenyl-1,3-thiazol-2-yl)hydrazone pKi: 7.67 Homo sapiens
1.4.3.4 4-methylcyclohexanone (4-phenyl-1,3-thiazol-2-yl)hydrazone pKi: 7.0 Homo sapiens
1.4.3.4 benzaldehyde (4-methyl-1,3-thiazol-2-yl)hydrazone pKi: 8.14 Homo sapiens
1.4.3.4 benzaldehyde (4-phenyl-1,3-thiazol-2-yl)hydrazone pKi: 5.92 Homo sapiens
1.4.3.4 cyclohexanone (4-phenyl-1,3-thiazol-2-yl)hydrazone pKi: 7.69 Homo sapiens
1.4.3.4 cyclopentanone (4-phenyl-1,3-thiazol-2-yl)hydrazone pKi: 6.85 Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
1.4.3.4 Homo sapiens P21397
-
-
1.4.3.4 Homo sapiens P27338
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.4.3.4 benzylamine + H2O + O2
-
 Homo sapiens benzaldehyde + NH3 + H2O2
-
 ?
1.4.3.4 serotonin + H2O + O2
-
 Homo sapiens (5-hydroxy-1H-indol-3-yl)acetaldehyde + NH3 + H2O2
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.4.3.4 MAO-A
-
 Homo sapiens
1.4.3.4 MAO-B
-
 Homo sapiens