EC Number | Cloned (Comment) | Organism |
---|---|---|
3.5.3.15 | promoter sequence determination and anaylsis 195 base pairs upstream from the transcription initiation site, primer extension method and determination of minimal promoter sequence, the promoter activity depends on MFZ1 and Sp1/Sp3 binding to their specific sites | Homo sapiens |
EC Number | Protein Variants | Comment | Organism |
---|---|---|---|
3.5.3.15 | additional information | the promoter activity of MFZ1- and Sp1-binding site mutants is reduced, overview | Homo sapiens |
EC Number | Metals/Ions | Comment | Organism | Structure |
---|---|---|---|---|
3.5.3.15 | Ca2+ | required for activity, calcium increases the expression of PAD1 and PAD2 | Homo sapiens |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.5.3.15 | keratin-L-arginine + H2O | Homo sapiens | PAD1 | keratin-L-citrulline + NH3 | - |
ir | |
3.5.3.15 | protein-L-arginine + H2O | Homo sapiens | - |
protein-L-citrulline + NH3 | - |
ir |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.5.3.15 | Homo sapiens | Q9ULC6 | isozyme PAD1 | - |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
3.5.3.15 | epidermis | isozyme PAD1 | Homo sapiens | - |
3.5.3.15 | HeLa cell | low expression level of PAD1 | Homo sapiens | - |
3.5.3.15 | keratinocyte | epidermal, isozyme PAD1, PAD1 and MFZ1 increase both during differentiation | Homo sapiens | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.5.3.15 | keratin-L-arginine + H2O | PAD1 | Homo sapiens | keratin-L-citrulline + NH3 | - |
ir | |
3.5.3.15 | protein-L-arginine + H2O | - |
Homo sapiens | protein-L-citrulline + NH3 | - |
ir |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
3.5.3.15 | PADI1 | - |
Homo sapiens |
3.5.3.15 | peptidylarginine deiminase type I | - |
Homo sapiens |