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Literature summary extracted from
- Investigation of the effects of some sulfonamide derivatives on the activities of glucose-6-phosphate dehydrogenase, 6-phospho gluconate dehydrogenase and glutathione reductase from human erythrocytes (2008), J. Enzyme Inhib. Med. Chem., 23, 418-423.
Activating Compound
| EC Number | Activating Compound | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.1.1.44 | 5-(3alpha-acetoxy-5-beta-cholanamido)-1,3,4-thiadiazole-2-sulfonamide | activates | Homo sapiens |  |
| 1.1.1.44 | 5-(3alpha-hydroxy-5-beta-cholanamido)-1,3,4-thiadiazole-2-sulfonamide | activates | Homo sapiens | |
| 1.1.1.49 | 5-(3alpha,12alpha-dihydroxy-5-beta-cholanamido)-1,3,4-thiadiazole-2-sulfonamide | weak activation | Homo sapiens | |
| 1.1.1.49 | 5-(3alpha,acetoxy-5-beta-cholanamido)-1,3,4-thiadiazole-2-sulfonamide | activates | Homo sapiens | |
| 1.1.1.49 | acetazolamide | activates | Homo sapiens | |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.1.1.43 | 5-(3alpha,7alpha,12alpha-triacetoxy-5-beta-cholanamido)-1,3,4-thiadiazole-2-sulfonamide | - |
Homo sapiens | |
| 1.1.1.43 | 5-(3alpha,7alpha,12alpha-trihydroxy-5-beta-cholanamido)-1,3,4-thiadiazole-2-sulfonamide | - |
Homo sapiens | |
| 1.1.1.43 | dorzolamide | - |
Homo sapiens | |
| 1.1.1.43 | additional information | not inhibited by 5-(3alpha-hydroxy-5-beta-cholanamido)-1,3,4-thiadiazole-2-sulfonamide, 5-(3alpha,12alpha-dihydroxy-5-beta-cholanamido)-1,3,4-thiadiazole-2-sulfonamide, 5-(3alpha,acetoxy-5-beta-cholanamido)-1,3,4-thiadiazole-2-sulfonamide, 5-(3,7,12-trioxo-5-beta-cholanamido)-1,3,4-thiadiazole-2-sulfonamide, and acetazolamide | Homo sapiens | |
| 1.1.1.44 | (4S)-trans-4-ethylammonio-6-methyl-5,6-dihydro-4H-thieno[2,3-b]thiopyran-2-sulfonamide 7,7-dioxide | i.e. dorzolamide, competitive | Homo sapiens | |
| 1.1.1.44 | 5-(3,7,12-trioxo-5-beta-cholanamido)-1,3,4-thiadiazole-2-sulfonamide | weak inhibition | Homo sapiens | |
| 1.1.1.44 | 5-(3alpha,7alpha,12alpha-triacetoxy-5-beta-cholanamido)-1,3,4-thiadiazole-2-sulfonamide | competitive | Homo sapiens | |
| 1.1.1.44 | 5-(3alpha,7alpha,12alpha-trihydroxy-5-beta-cholanamido)-1,3,4-thiadiazole-2-sulfonamide | competitive | Homo sapiens | |
| 1.1.1.49 | 5-(3alpha,7alpha,12alpha-triacetoxy-5-beta-cholanamido)-1,3,4-thiadiazole-2-sulfonamide | weak inhibition | Homo sapiens | |
| 1.1.1.49 | 5-(3alpha,7alpha,12alpha-trihydroxy-5-beta-cholanamido)-1,3,4-thiadiazole-2-sulfonamide | weak inhibition | Homo sapiens | |
| 1.8.1.7 | 5-(3alpha,12alpha-dihydroxy-5-beta-cholanamido)-1,3,4-thiadiazole-2-sulfonamide | - |
Homo sapiens | |
| 1.8.1.7 | 5-(3alpha-hydroxy-5-beta-cholanamido)-1,3,4-thiadiazole-2-sulfonamide | - |
Homo sapiens | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.1.1.43 | Homo sapiens | - |
- |
- |
| 1.1.1.44 | Homo sapiens | - |
- |
- |
| 1.1.1.49 | Homo sapiens | - |
- |
- |
| 1.8.1.7 | Homo sapiens | - |
- |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 1.1.1.43 | ammonium sulfate precipitation, 2',5'-ADP Sepharose 4B affinity chromatography, and Sephadex G-200 gel filtration | Homo sapiens |
| 1.1.1.44 | - |
Homo sapiens |
| 1.1.1.49 | - |
Homo sapiens |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 1.1.1.43 | erythrocyte | - |
Homo sapiens | - |
| 1.1.1.49 | erythrocyte | - |
Homo sapiens | - |
| 1.8.1.7 | erythrocyte | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.1.1.44 | 6-phospho-D-gluconate + NADP+ | - |
Homo sapiens | D-ribulose 5-phosphate + CO2 + NADPH + H+ | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 1.1.1.43 | 6-phosphogluconate dehydrogenase | - |
Homo sapiens |
| 1.1.1.44 | 6PGD | - |
Homo sapiens |
| 1.1.1.49 | G6PD | - |
Homo sapiens |
Ki Value [mM]
| EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 1.1.1.43 | 0.0042 | - |
5-(3alpha,7alpha,12alpha-triacetoxy-5-beta-cholanamido)-1,3,4-thiadiazole-2-sulfonamide | - |
Homo sapiens | |
| 1.1.1.43 | 0.0878 | - |
5-(3alpha,7alpha,12alpha-trihydroxy-5-beta-cholanamido)-1,3,4-thiadiazole-2-sulfonamide | - |
Homo sapiens | |
| 1.1.1.43 | 3.145 | - |
dorzolamide | - |
Homo sapiens | |
| 1.1.1.44 | 0.0042 | - |
5-(3alpha,7alpha,12alpha-triacetoxy-5-beta-cholanamido)-1,3,4-thiadiazole-2-sulfonamide | - |
Homo sapiens | |
| 1.1.1.44 | 0.0878 | - |
5-(3alpha,7alpha,12alpha-trihydroxy-5-beta-cholanamido)-1,3,4-thiadiazole-2-sulfonamide | - |
Homo sapiens | |
| 1.1.1.44 | 3.14 | - |
(4S)-trans-4-ethylammonio-6-methyl-5,6-dihydro-4H-thieno[2,3-b]thiopyran-2-sulfonamide 7,7-dioxide | - |
Homo sapiens | |
| 1.8.1.7 | 0.0061 | - |
5-(3alpha,12alpha-dihydroxy-5-beta-cholanamido)-1,3,4-thiadiazole-2-sulfonamide | - |
Homo sapiens | |
| 1.8.1.7 | 0.0723 | - |
5-(3alpha-hydroxy-5-beta-cholanamido)-1,3,4-thiadiazole-2-sulfonamide | - |
Homo sapiens | |
IC50 Value
| EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|---|
| 1.1.1.43 | 0.00253 | - |
- |
Homo sapiens | 5-(3alpha,7alpha,12alpha-triacetoxy-5-beta-cholanamido)-1,3,4-thiadiazole-2-sulfonamide | |
| 1.1.1.43 | 0.0601 | - |
- |
Homo sapiens | 5-(3alpha,7alpha,12alpha-trihydroxy-5-beta-cholanamido)-1,3,4-thiadiazole-2-sulfonamide | |
| 1.1.1.43 | 1.41 | - |
- |
Homo sapiens | dorzolamide | |
| 1.1.1.44 | 0.00253 | - |
- |
Homo sapiens | 5-(3alpha,7alpha,12alpha-triacetoxy-5-beta-cholanamido)-1,3,4-thiadiazole-2-sulfonamide | |
| 1.1.1.44 | 0.0601 | - |
- |
Homo sapiens | 5-(3alpha,7alpha,12alpha-trihydroxy-5-beta-cholanamido)-1,3,4-thiadiazole-2-sulfonamide | |
| 1.1.1.44 | 1.41 | - |
- |
Homo sapiens | (4S)-trans-4-ethylammonio-6-methyl-5,6-dihydro-4H-thieno[2,3-b]thiopyran-2-sulfonamide 7,7-dioxide | |
| 1.8.1.7 | 0.0045 | - |
- |
Homo sapiens | 5-(3alpha,12alpha-dihydroxy-5-beta-cholanamido)-1,3,4-thiadiazole-2-sulfonamide | |
| 1.8.1.7 | 0.0471 | - |
- |
Homo sapiens | 5-(3alpha-hydroxy-5-beta-cholanamido)-1,3,4-thiadiazole-2-sulfonamide | |
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