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Literature summary extracted from

  • Ramirez, D.M.; Andersson, S.; Russell, D.W.
    Neuronal expression and subcellular localization of cholesterol 24-hydroxylase in the mouse brain (2008), J. Comp. Neurol., 507, 1676-1693.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.14.14.25 gene CYP46A1, expressionin CHO-K1 cells and HEK-293 cells Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.14.14.25 endoplasmic reticulum dendritic Mus musculus 5783
-
1.14.14.25 microsome
-
 Mus musculus
-
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.14.14.25 Fe2+ a cytochrome P450 enzyme Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.14.25 cholesterol + [reduced NADPH-hemoprotein reductase] + H+ + O2 Mus musculus the enzyme is required for learning and memory formation, mice deficient in CYP46A1 exhibit impaired learning and defective hippocampal long-term potentiation, overview (24S)-24-hydroxycholesterol + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.14.25 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.14.25 brain
-
 Mus musculus
-
1.14.14.25 cerebellum cerebellar interneurons and Purkinje cells Mus musculus
-
1.14.14.25 cerebral cortex pyramidal neurons Mus musculus
-
1.14.14.25 dendritic cell
-
 Mus musculus
-
1.14.14.25 hippocampus pyramidal neurons Mus musculus
-
1.14.14.25 additional information immunohistochemic analysis of enzyme distribution, overview Mus musculus
-
1.14.14.25 neuron
-
 Mus musculus
-
1.14.14.25 Purkinje cell in the cerebellum Mus musculus
-
1.14.14.25 retina ganglion cells Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.14.25 cholesterol + [reduced NADPH-hemoprotein reductase] + H+ + O2
-
 Mus musculus (24S)-24-hydroxycholesterol + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
1.14.14.25 cholesterol + [reduced NADPH-hemoprotein reductase] + H+ + O2 the enzyme is required for learning and memory formation, mice deficient in CYP46A1 exhibit impaired learning and defective hippocampal long-term potentiation, overview Mus musculus (24S)-24-hydroxycholesterol + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.14.25 CYP46A1
-
 Mus musculus

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.14.25 cytochrome P450 a cytochrome P450 enzyme Mus musculus
1.14.14.25 NADPH
-
 Mus musculus